Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A Case Control Study in the Dutch Childhood Cancer Survivor Study
BACKGROUND: Plasma biomarkers may aid in the detection of anthracycline-related cardiomyopathy (ACMP). However, the cur-rently available biomarkers have limited diagnostic value in long-term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. METHODS AND RESULTS: We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction <45%, 29 anthracycline-treated controls with left ventricular ejection fraction ≥53% matched on sex, time after cancer, and anthracy-cline dose, and 29 patients with gen... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Verlag/Hrsg.: |
WILEY
|
Schlagwörter: | anthracycline-related cardiomyopathy / biomarkers / cancer therapy-related cardiac dysfunction / cardio-oncology / chemokine ligands / childhood cancer survivors |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27051197 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://discovery.ucl.ac.uk/id/eprint/10158625/1/JAHA.121.025935.pdf |