ANTENATAL TREATMENT IN TWO DUTCH FAMILIES WITH PYRIDOXINE DEPENDENT SEIZURES

Pyridoxine-dependent seizure (PDS) is a rare, autosomal recessive disorder characterized by drug-resistant neonatal seizures. About 20% of mothers experience abnormal foetal movements during pregnancy, and birth is complicated in a third of children. It is thought that early postnatal treatment improves cognitive development. However, the benefit of antenatal treatment is still under debate. Some case reports support favourable outcome of antenatal treatment (n = 3 patients) while other case reports show no or little advantage in outcome (n = 5). We present two well documented Dutch families w... Mehr ...