FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians

Background: HLA is the only genetic risk factor for rheumatoid arthritis (RA) that was consistently observed in different populations. A number of other genes such as PTPN22 and PADI4 showed population specific association with RA susceptibility. Recently Fc receptor-like 3 (FCRL3) gene was found to be associated with RA susceptibility in Japanese, but with conflicting results in other populations. Objective : To investigate the association of FCRL3 polymorphism with RA susceptibility and severity in the Dutch Caucasian RA patients, as well as performing a meta-analysis to reveal the contribut... Mehr ...