Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations
International audience ; Celiac disease is an inflammatory enteropathy caused by intolerance to gluten. Previous linkage studies in the Dutch, Finnish and Hungarian populations have revealed a locus on chromosome 6q21-22 conferring susceptibility to celiac disease. This locus has previously been implicated in susceptibility to other autoimmune diseases such as Crohn's disease and type 1 diabetes. We performed finemapping on 446 independent individuals with celiac disease and 641 controls of Dutch origin, testing 872 tagging SNPs in a 22 Mb region of chromosome 6. The twelve most promising SNPs... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2011 |
Verlag/Hrsg.: |
HAL CCSD
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Schlagwörter: | celiac / association / linkage |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27010399 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hal.archives-ouvertes.fr/hal-00614742 |