Abstract Insectivore remains are not common in the Lower Oligocene of Europe. For this reason, the study of the earliest Oligocene insectivore fauna (MP 21) from Boutersem and Hoogbutsel, all together yielding nine species, representing five families, constitutes an important progress in the knowledge of the Late Eocene and Early Oligocene insectivore evolution. Some of the genera discovered in Belgium are known from upper Eocene sites ( Saturninia, Amphidozotherium, Euronyctia, Eotalpa ), whereas others are not known before the Oligocene ( Butselia, Tetracus , Heterosoricinae ind.). The co-occurrence of primitive species of Nyctitheriidae with modern forms belonging to the Plesiosoricidae, Talpidae and Erinaceidae at the Eocene-Oligocene boundary suggests a transition fauna. Between the Priabonian (Late Eocene) and the Rupelian (Early Oligocene), the endemic European insectivores were in competition with the new immigrants. This faunal turnover is generally accepted as the ‘Grande Coupure’ event (the MP 21 event).