Abstract: Simple Summary Lung cancer is the most common and deadliest cancer worldwide, and the number of new cases per year is expected to grow. Belgium is among the top 10 countries with most new cases of lung cancer in the world, with lung cancer incidence accounting for 11.8% of all cancers diagnosed and 23.8% of all cancer-related deaths. This study aimed to determine the overall acceptability of a lung cancer screening program in the Flemish population and the main factors that would influence the overall acceptability of such a program. Modeling of the results of a questionnaire distributed to the Flemish population showed 92% acceptability. Furthermore, policymakers should aim for it to be reimbursed, and campaigns should be gender-specific, focused on those with lower educational and socioeconomic status, along with investment in increasing total knowledge about lung cancer and about protective factors. Lung cancer is the most common and deadliest cancer in the world, and its incidence is expected to grow. Nonetheless, this growth can be contained through smoking cessation programs and effective lung cancer screening programs. In 2018, Belgium had the seventh highest incidence of lung cancer in the world, with lung cancer incidence accounting for 11.8% of all cancers diagnosed and 23.8% of all cancer-related deaths that same year. The aims of this study were to determine the overall acceptability of a lung cancer screening program in the Flemish population and to determine the main factors that would influence the overall acceptability of such a program. A questionnaire-based cross-sectional study was performed in the Flemish population and distributed online and on paper. The results are presented with the variables of interest and the main outcome, i.e., the acceptability of participating in such a program if implemented. Odds ratios were used to compare acceptability between subgroups. A multivariate regression model was used to determine the key factors that would have the largest impact on the ...