Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts.

Journal Article; ; BACKGROUND Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight. METHODS We used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA... Mehr ...

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Verfasser: Clemente, Diana B P
Casas, Maribel
Vilahur, Nadia
Begiristain, Haizea
Bustamante, Mariona
Carsin, Anne-Elie
Fernández, Mariana F
Fierens, Frans
Gyselaers, Wilfried
Iñiguez, Carmen
Janssen, Bram G
Lefebvre, Wouter
Llop, Sabrina
Olea, Nicolás
Pedersen, Marie
Pieters, Nicky
Santa Marina, Loreto
Souto, Ana
Tardón, Adonina
Vanpoucke, Charlotte
Vrijheid, Martine
Sunyer, Jordi
Nawrot, Tim S
Dokumenttyp: research article
Erscheinungsdatum: 2016
Verlag/Hrsg.: National Institute of Environmental Health Sciences (NIEHS)
Schlagwörter: Contaminación del aire / Bélgica / Peso al nacer / ADN mitocondrial / Femenino / Desarrollo fetal / Retardo del crecimiento fetal / Genes mitocondriales / Modelos Lineales / Mitocondrias / Dióxido de nitrógeno / Placenta / Embarazo / España / Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Air Pollution / Medical Subject Headings::Geographicals::Geographic Locations::Europe::Belgium / Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Birth Weight / Medical Subject Headings::Chemicals and Drugs::Nucleic Acids / Nucleotides / and Nucleosides::Nucleic Acids::DNA::DNA / Circular::DNA / Mitochondrial / Medical Subject Headings::Check Tags::Female / Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Fetal Development / Medical Subject Headings::Diseases::Pathological Conditions / Signs and Symptoms::Pathologic Processes::Growth Disorders::Fetal Growth Retardation / Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes / Medical Subject Headings::Analytical / Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models / Statistical::Linear Models / Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria / Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Gases::Nitrogen Oxides::Nitrogen Dioxide / Medical Subject Headings::Anatomy::Embryonic Structures::Placenta / Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy / Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26987834
Datenquelle: BASE; Originalkatalog
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Link(s) : http://hdl.handle.net/10668/2555