Land-use changes are frequently indicated to be one of the main human-induced factors influencing the groundwater system. For land-use change, groundwater research has mainly focused on the change in water quality thereby neglecting changes in quantity. The objective of this paper is to assess the impact of land-use changes, from 2000 until 2020, on the hydrological balance and in particular on groundwater quantity, as results from a case study in the Kleine Nete basin, Belgium. New is that this study tests a methodology, which couples a land-use change model with a water balance and a steady-state groundwater model. Although the averages found appear to indicate small changes in the groundwater system, spatial analysis shows that much larger changes are located near the major cities in the study area. Hence, spatial planning should take better account of effects of land-use change on the groundwater system and define mitigating actions for reducing the negative impacts of land-use change.