Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers
Introduction: Linezolid is a last-resort antibiotic for infections caused by multidrug-resistant microorganisms. It is widely used for off-label indications and for longer than recommended treatment durations, exposing patients at higher risk of adverse drug reactions (ADRs), notably thrombocytopenia. This study aimed to investigate ADR incidence and risk factors, identify thrombocytopenia-related trough levels based on treatment duration, and evaluate the performance of predictive scores for ADR development. Methods: Adult in- and outpatients undergoing linezolid therapy were enrolled in thre... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2024 |
Schlagwörter: | Immunologie / adverse drug reaction / anemia / Buzelé score / linezolid / neurotoxicity / therapeutic drug monitoring / thrombocytopenia |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26916756 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/371610 |