Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers

Introduction: Linezolid is a last-resort antibiotic for infections caused by multidrug-resistant microorganisms. It is widely used for off-label indications and for longer than recommended treatment durations, exposing patients at higher risk of adverse drug reactions (ADRs), notably thrombocytopenia. This study aimed to investigate ADR incidence and risk factors, identify thrombocytopenia-related trough levels based on treatment duration, and evaluate the performance of predictive scores for ADR development. Methods: Adult in- and outpatients undergoing linezolid therapy were enrolled in thre... Mehr ...

Verfasser: Thirot, Hélène
Fage, David
Leonhardt, Antonia
Clevenbergh, Philippe
Besse-Hammer, Tatiana
Yombi, Jean-Cyr
Cornu, Olivier
Briquet, Caroline
Hites, Maya
Jacobs, Frédérique
Wijnant, Gert Jan
Wicha, Sebastian Georg
Cotton, Frédéric
Tulkens, Paul M.
Spinewine, Anne
Van Bambeke, Françoise
Dokumenttyp: Artikel
Erscheinungsdatum: 2024
Schlagwörter: Immunologie / adverse drug reaction / anemia / Buzelé score / linezolid / neurotoxicity / therapeutic drug monitoring / thrombocytopenia
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26916756
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/371610