Predictors of treatment toxicity and prognosis in pediatric acute lymphoblastic leukemia in Belgian and Vietnamese populations

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children, representing nearly one-third of all pediatric cancers. Although current treatment protocols can cure approximately 80% of pediatric ALL patients, a number of children will relapse, with a relapse rate shown to vary within a group of patients with similar risk even though their leukemia blast carry the same characteristics. Indeed, genetic variations involved in drug metabolism could, at least partially, be responsible for heterogeneous responses to standardized leukemia treatments, hence requiring more persona... Mehr ...