Susceptibility of human plasmodium knowlesi infections to anti-malarials
Background: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure. Therefore, adequate response to available anti-malarial treatments is assumed. Methods: Here the ex vivo sensitivity of human P. knowlesi isolates in Malaysian Borneo were studied, using a WHO schizont maturation assay modified to accommodate the quotidian life cycle of this parasite. The in vitro sensitivities of P. knowlesi H strain adapted from a primate infection to in vit... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2013 |
Reihe/Periodikum: | Fatih , F A , Staines , H M , Siner , A , Ahmed , M A , Woon , L C , Pasini , E M , Kocken , C H M , Singh , B , Cox Singh , J & Krishna , S 2013 , ' Susceptibility of human plasmodium knowlesi infections to anti-malarials ' , Malaria Journal , vol. 12 , 425 . https://doi.org/10.1186/1475-2875-12-425 |
Schlagwörter: | Artemisinin / Artemether / Artesunate / Dihydroartemisinin / DHA / Chloroquine / Mefloquine / Malaria / In-vitro / Mefloquine resistance / Vivax malaria / PFMDR1 gene / Falciparum / Malaysia / Sensitivity / Sabah / Erythrocytes / Adaptation |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26883686 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research-portal.st-andrews.ac.uk/en/researchoutput/susceptibility-of-human-plasmodium-knowlesi-infections-to-antimalarials(df24b405-4907-4da4-bdab-50098177aeb9).html |