Determination of the Status of Helicobacter Pylori SabA Gene in Relation to Clinical Findings

Background: Many Helicobacter pylori strains express adhesin proteins that bind to specific host-cell macromolecule receptors, like sialic acid binding adhesion (sabA). SabA-expressing strains have been associated with gastric cancer and negatively associated with duodenal ulcers. The aim of this study was to determine the status of sabA gene of H. pylori and its association with the clinical diseases in Iranian dyspeptic pateints.Methods: Eighty six biopsy block samples that were positive for H. pylori according Geimsa staining were included in this study. Genomic DNA was extracted from paraf... Mehr ...