Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia
ABSTRACT Plasmodium knowlesi causes severe and fatal malaria in Malaysia. Microscopic misdiagnosis is common and may delay appropriate treatment. P. knowlesi can cross-react with “species-specific” parasite lactate dehydrogenase (pLDH) monoclonal antibodies used in rapid diagnostic tests (RDTs) to detect P. falciparum and P. vivax . At one tertiary-care hospital and two district hospitals in Sabah, we prospectively evaluated two combination RDTs for malaria diagnosis by using both a pan- Plasmodium -pLDH (pan-pLDH)/ P. falciparum -specific-pLDH ( Pf -pLDH) RDT (OptiMAL-IT) and a non- P. falcip... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2014 |
Reihe/Periodikum: | Journal of Clinical Microbiology ; volume 52, issue 6, page 2053-2060 ; ISSN 0095-1137 1098-660X |
Verlag/Hrsg.: |
American Society for Microbiology
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Schlagwörter: | Microbiology (medical) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26861369 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1128/jcm.00181-14 |