Next generation sequencing characterizes HLA diversity in a registry population from the Netherlands
Next generation DNA sequencing is used to determine the HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3/4/5, and ‐DQB1 assignments of 1009 unrelated volunteers for the unrelated donor registry in The Netherlands. The analysis characterizes all HLA exons and introns for class I alleles; at least exons 2 to 3 for HLA‐DRB1; and exons 2 to 6 for HLA‐DQB1. Of the distinct alleles present, there are 229 class I and 71 class II; 36 of these alleles are novel. The majority (approximately 98%) of the cumulative allele frequency at each locus is contributed by alleles that appear three or more times. Alleles encoding prote... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2019 |
Reihe/Periodikum: | HLA ; volume 93, issue 6, page 474-483 ; ISSN 2059-2302 2059-2310 |
Verlag/Hrsg.: |
Wiley
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Schlagwörter: | Genetics / Immunology / Immunology and Allergy |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26851596 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1111/tan.13535 |