Clinical, genetic, and histological features of centronuclear myopathy in the Netherlands
Abstract Centronuclear myopathy (CNM) is a genetically heterogeneous congenital myopathy characterized by muscle weakness, atrophy, and variable degrees of cardiorespiratory involvement. The clinical severity is largely explained by genotype ( DNM2 , MTM1 , RYR1, BIN1, TTN , and other rarer genetic backgrounds), specific mutation(s), and age of the patient. The histopathological hallmark of CNM is the presence of internal centralized nuclei on muscle biopsy. Information on the phenotypical spectrum, subtype prevalence, and phenotype–genotype correlations is limited. To characterize CNM more co... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Clinical Genetics ; volume 100, issue 6, page 692-702 ; ISSN 0009-9163 1399-0004 |
Verlag/Hrsg.: |
Wiley
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Schlagwörter: | Genetics (clinical) / Genetics |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26851372 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1111/cge.14054 |