Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

Summary Background Azathioprine ( AZA ) and mercaptopurine ( MP ) are the cornerstone of steroid‐sparing strategies in autoimmune hepatitis ( AIH ). Up to 20% of patients do not tolerate or respond to these regimens. Aim To evaluate retrospectively the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. Methods Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands. Indications for TG treatment were intolerable side effects on AZA or MP (n = 38), insufficient response (n = 11)... Mehr ...