Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Abstract Antidepressants are an effective treatment for major depressive disorder (MDD), although individual response is unpredictable and highly variable. Whilst the mode of action of antidepressants is incompletely understood, many medications are associated with changes in DNA methylation in genes that are plausibly linked to their mechanisms. Studies of DNA methylation may therefore reveal the biological processes underpinning the efficacy and side effects of antidepressants. We performed a methylome-wide association study (MWAS) of self-reported antidepressant use accounting for lifestyle... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Molecular Psychiatry ; volume 27, issue 3, page 1647-1657 ; ISSN 1359-4184 1476-5578 |
Verlag/Hrsg.: |
Springer Science and Business Media LLC
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Schlagwörter: | Cellular and Molecular Neuroscience / Psychiatry and Mental health / Molecular Biology |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26849649 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1038/s41380-021-01412-7 |