Effectiveness of Blended Cognitive Behavioral Therapy Versus Treatment as Usual for Depression in Routine Specialized Mental Healthcare: E-COMPARED Trial in the Netherlands

Abstract Background The general aim of this study was to investigate the effectiveness of blended Cognitive Behavioral Therapy (bCBT) as compared to Treatment as Usual (TAU) for depression in specialized routine mental healthcare in the Netherlands. We further explored a range of secondary outcome variables, including quality of life, clinical response, remission and reliable improvement, as well as clinical deterioration and potential negative effects of treatment. Methods n = 103 patients with Major Depressive Disorder were recruited as part of the E-COMPARED project, and randomly allocated... Mehr ...