Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder
Individual response to stress is correlated with neuroticism and is an important predictor of both neuroticism and the onset of major depressive disorder (MDD). Identification of the genetics underpinning individual differences in response to negative events (stress-sensitivity) may improve our understanding of the molecular pathways involved, and its association with stress-related illnesses. We sought to generate a proxy for stress-sensitivity through modelling the interaction between SNP allele and MDD status on neuroticism score in order to identify genetic variants that contribute to the... Mehr ...
Verfasser: |
Abdellaoui, Abdel
Dolan, Conor V.
Hottenga, Jouke Jan
Mbarek, Hamdi
Middeldorp, Christel M.
Nivard, Michel G.
Posthuma, Danielle
Willemsen, Gonneke
Boomsma, Dorret I.
De Geus, E. J.C. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
Abdellaoui , A , Dolan , C V , Hottenga , J J , Mbarek , H , Middeldorp , C M , Nivard , M G , Posthuma , D , Willemsen , G , Boomsma , D I , De Geus , E J C , Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2018 , ' Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder ' , PLoS ONE , vol. 13 , no. 12 , e0209160 , pp. 1-29 . https://doi.org/10.1371/journal.pone.0209160 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845523 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/fc02ea29-edcf-44f0-9f0d-e9ba415aba32 |