Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on 123 circulating metabolic traits quantified by nuclear magnetic resonance metabolomics from up to 24,925 individuals and identify eight novel loci for amino acids, pyruvate and fatty... Mehr ...
| Verfasser: |
Kettunen, J.
Demirkan, A.
Würtz, P.
Draisma, H.H.M.
Haller, T.
Rawal, R.
Vaarhorst, A.A.M.
Kangas, A.J.
Lyytikäinen, L.P.
Pirinen, M.
Pool, R.
Sarin, A.-P.
Soininen, P.
Tukiainen, T.
Wang, Q.
Tiainen, M.
Tynkkynen, T.
Amin, N.
Zeller, T.
Beekman, M.
Deelen, J.
Willems van Dijk, K.
Esko, T.
Hottenga, J.J.
van Leeuwen, E.M.
Lehtimäki, T.
Mihailov, E.
Rose, R.J.
de Craen, A.J.
Gieger, C.
Kähönen, M.
Perola, M.
Blankenberg, S.
Savolainen, M.J.
Verhoeven, A.
Viikari, J.
Willemsen, G.
Boomsma, D.I.
van Duijn, C.M.
Eriksson, J.
Jula, A.
Järvelin, M.R.
Kaprio, J.
Metspalu, A.
Raitakari, O.
Salomaa, V.
Slagboom, P.E.
Waldenberger, M.
Ripatti, S.
Ala-Korpela, M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
Kettunen , J , Demirkan , A , Würtz , P , Draisma , H H M , Haller , T , Rawal , R , Vaarhorst , A A M , Kangas , A J , Lyytikäinen , L P , Pirinen , M , Pool , R , Sarin , A-P , Soininen , P , Tukiainen , T , Wang , Q , Tiainen , M , Tynkkynen , T , Amin , N , Zeller , T , Beekman , M , Deelen , J , Willems van Dijk , K , Esko , T , Hottenga , J J , van Leeuwen , E M , Lehtimäki , T , Mihailov , E , Rose , R J , de Craen , A J , Gieger , C , Kähönen , M , Perola , M , Blankenberg , S , Savolainen , M J , Verhoeven , A , Viikari , J , Willemsen , G , Boomsma , D I , van Duijn , C M , Eriksson , J , Jula , A , Järvelin , M R , Kaprio , J , Metspalu , A , Raitakari , O , Salomaa , V , Slagboom , P E , Waldenberger , M , Ripatti , S & Ala-Korpela , M 2016 , ' Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA ' , Nature Communications , vol. 7 , 11122 . https://doi.org/10.1038/ncomms11122 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845398 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/ec4670e0-907c-4528-916e-039a0a08e169 |
