Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in -1/470,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive l... Mehr ...
Verfasser: |
Day, F.R.
Ruth, K.S.
Thompson, D.J.
Lunetta, K.L.
Pervjakova, N.
Chasman, D.I.
Stolk, L.
Finucane, H.K.
Sulem, P.
Bulik-Sullivan, B.K.
Esko, T.
Johnson, A.D.
Elks, C.E.
Franceschini, N.
He, C.
Altmaier, E.
Brody, J.A.
Franke, L.L.
Huffman, J.E.
Keller, M.F.
McArdle, P.F.
Nutile, T.
Porcu, E.
Robino, A.
Rose, L.M.
Schick, U.M.
Smith, J.A.
Teumer, A.
Traglia, M.
Vuckovic, D.
Yao, J.
Zhao, W.
Albrecht, E.
Amin, N.
Corre, T.
Hottenga, J.J.
Mangino, M.
Smith, A.V.
Tanaka, T.
Abecasis, G.R.
Andrulis, I.L.
Anton-Culver, H.
Antoniou, A.C.
Arndt, V.
Arnold, A.M.
Barbieri, C.
Beckmann, M.W.
Beeghly-Fadiel, A.
Benitez, J.
Bernstein, L.
Bielinski, S.J.
Blomqvist, C.
Boerwinkle, E.
Bogdanova, N.V.
Bojesen, S.E.
Bolla, M.K.
Borresen-Dale, A.L.
Boutin, T.S.
Brauch, H.
Brenner, H.
Brüning, T.
Burwinkel, B.
Campbell, A.
Campbell, H.
Chanock, S.J.
Chapman, J.R.
Ida Chen, Y.D.
Chenevix-Trench, G.
Couch, F.J.
Coviello, A.D.
Cox, A.
Czene, K.
Darabi, H.
De Vivo, I.
Demerath, E.W.
Dennis, J.
Devilee, P.
Dörk, T.
dos-Santos-Silva, I.
Dunning, A.M.
Eicher, J.D.
Fasching, P.A.
Faul, J.D.
Figueroa, J.
Flesch-Janys, D.
Gandin, I.
Garcia, M.E.
García-Closas, M.
Giles, G.G.
Girotto, G.G.
Goldberg, M.S.
González-Neira, A.
Goodarzi, M.O.
Grove, M.L.
Gudbjartsson, D.F.
Guénel, P.
Guo, X.
Haiman, C.A.
Hall, P.
Hamann, U.
Henderson, B.E.
Hocking, L.J.
Hofman, A.
Homuth, G.
Hooning, M.J.
Hopper, J.L.
Hu, F.B.
Huang, J.
Humphreys, K.
Hunter, D.J.
Jakubowska, A.
Jones, S.E.
Kabisch, M.
Karasik, D.
Knight, J.A.
Kolcic, I.
Kooperberg, C.
Kosma, V.M.
Kriebel, J.
Kristensen, V.
Lambrechts, D.
Langenberg, C.
Li, J.
Li, X.
Lindström, S.
Liu, Y.
Luan, J.
Lubinski, J.
Mägi, R.
Mannermaa, A.
Manz, J.
Margolin, S.
Marten, J.
Martin, N.G.
Masciullo, C.
Meindl, A.
Michailidou, K.
Mihailov, E.
Milani, L.
Milne, R.L.
Müller-Nurasyid, M.
Nalls, M.
Neale, B.M.
Nevanlinna, H.
Neven, P.
Newman, A.B.
Nordestgaard, B.G.
Olson, J.E.
Padmanabhan, S.
Peterlongo, P.
Peters, U.
Petersmann, A.
Peto, J.
Pharoah, P.D.P.
Pirastu, N.N.
Pirie, A.
Pistis, G.
Polasek, O.
Porteous, D.
Psaty, B.M.
Pylkäs, K.
Radice, P.
Raffel, L.J.
Rivadeneira, F.
Rudan, I.
Rudolph, A.
Ruggiero, D.
Sala, C.F.
Sanna, S.
Sawyer, E.J.
Schlessinger, D.
Schmidt, M.K.
Schmidt, F.
Schmutzler, R.K.
Schoemaker, M.J.
Scott, R.A.
Seynaeve, C.M.
Simard, J.
Sorice, R.
Southey, M.C.
Stöckl, D.
Strauch, K.
Swerdlow, A.
Taylor, K.D.
Thorsteinsdottir, U.
Toland, A.E.
Tomlinson, I.
Truong, T.
Tryggvadottir, L.
Turner, S.T.
Vozzi, D.
Wang, Q.
Wellons, M.
Willemsen, G.
Wilson, J.F.
Winqvist, R.
Wolffenbuttel, B.H.R.
Wright, A.F.
Yannoukakos, D.
Zemunik, T.
Zheng, W.
Zygmunt, M.
Bergmann, S.
Boomsma, D.I.
Buring, J.E.
Ferrucci, L.
Montgomery, G.W.
Gudnason, V.
Spector, T.D.
van Duijn, C.M.
Alizadeh, BZ
Ciullo, M.
Crisponi, L.
Easton, D.F.
Gasparini, P.P.
Gieger, C.
Harris, T.B.
Hayward, C.
Kardia, S.L.R.
Kraft, P.
McKnight, B.
Metspalu, A.
Morrison, A.C.
Reiner, A.P.
Ridker, P.M.
Rotter, J.I.
Toniolo, D.
Uitterlinden, A.G.
Ulivi, S.
Völzke, H.
Wareham, N.J.
Weir, D.R.
Yerges-Armstrong, L.M.
Price, A.L.
Stefansson, K.
Visser, J.A.
Ong, K.K.
Chang-Claude, J.
Murabito, J.M.M.
Perry, J.R.B.
Murray, A. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Day , F R , Ruth , K S , Thompson , D J , Lunetta , K L , Pervjakova , N , Chasman , D I , Stolk , L , Finucane , H K , Sulem , P , Bulik-Sullivan , B K , Esko , T , Johnson , A D , Elks , C E , Franceschini , N , He , C , Altmaier , E , Brody , J A , Franke , L L , Huffman , J E , Keller , M F , McArdle , P F , Nutile , T , Porcu , E , Robino , A , Rose , L M , Schick , U M , Smith , J A , Teumer , A , Traglia , M , Vuckovic , D , Yao , J , Zhao , W , Albrecht , E , Amin , N , Corre , T , Hottenga , J J , Mangino , M , Smith , A V , Tanaka , T , Abecasis , G R , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Arndt , V , Arnold , A M , Barbieri , C , Beckmann , M W , Beeghly-Fadiel , A , Benitez , J , Bernstein , L , Bielinski , S J , Blomqvist , C , Boerwinkle , E , Bogdanova , N V , Bojesen , S E , Bolla , M K , Borresen-Dale , A L , Boutin , T S , Brauch , H , Brenner , H , Brüning , T , Burwinkel , B , Campbell , A , Campbell , H , Chanock , S J , Chapman , J R , Ida Chen , Y D , Chenevix-Trench , G , Couch , F J , Coviello , A D , Cox , A , Czene , K , Darabi , H , De Vivo , I , Demerath , E W , Dennis , J , Devilee , P , Dörk , T , dos-Santos-Silva , I , Dunning , A M , Eicher , J D , Fasching , P A , Faul , J D , Figueroa , J , Flesch-Janys , D , Gandin , I , Garcia , M E , García-Closas , M , Giles , G G , Girotto , G G , Goldberg , M S , González-Neira , A , Goodarzi , M O , Grove , M L , Gudbjartsson , D F , Guénel , P , Guo , X , Haiman , C A , Hall , P , Hamann , U , Henderson , B E , Hocking , L J , Hofman , A , Homuth , G , Hooning , M J , Hopper , J L , Hu , F B , Huang , J , Humphreys , K , Hunter , D J , Jakubowska , A , Jones , S E , Kabisch , M , Karasik , D , Knight , J A , Kolcic , I , Kooperberg , C , Kosma , V M , Kriebel , J , Kristensen , V , Lambrechts , D , Langenberg , C , Li , J , Li , X , Lindström , S , Liu , Y , Luan , J , Lubinski , J , Mägi , R , Mannermaa , A , Manz , J , Margolin , S , Marten , J , Martin , N G , Masciullo , C , Meindl , A , Michailidou , K , Mihailov , E , Milani , L , Milne , R L , Müller-Nurasyid , M , Nalls , M , Neale , B M , Nevanlinna , H , Neven , P , Newman , A B , Nordestgaard , B G , Olson , J E , Padmanabhan , S , Peterlongo , P , Peters , U , Petersmann , A , Peto , J , Pharoah , P D P , Pirastu , N N , Pirie , A , Pistis , G , Polasek , O , Porteous , D , Psaty , B M , Pylkäs , K , Radice , P , Raffel , L J , Rivadeneira , F , Rudan , I , Rudolph , A , Ruggiero , D , Sala , C F , Sanna , S , Sawyer , E J , Schlessinger , D , Schmidt , M K , Schmidt , F , Schmutzler , R K , Schoemaker , M J , Scott , R A , Seynaeve , C M , Simard , J , Sorice , R , Southey , M C , Stöckl , D , Strauch , K , Swerdlow , A , Taylor , K D , Thorsteinsdottir , U , Toland , A E , Tomlinson , I , Truong , T , Tryggvadottir , L , Turner , S T , Vozzi , D , Wang , Q , Wellons , M , Willemsen , G , Wilson , J F , Winqvist , R , Wolffenbuttel , B H R , Wright , A F , Yannoukakos , D , Zemunik , T , Zheng , W , Zygmunt , M , Bergmann , S , Boomsma , D I , Buring , J E , Ferrucci , L , Montgomery , G W , Gudnason , V , Spector , T D , van Duijn , C M , Alizadeh , BZ , Ciullo , M , Crisponi , L , Easton , D F , Gasparini , P P , Gieger , C , Harris , T B , Hayward , C , Kardia , S L R , Kraft , P , McKnight , B , Metspalu , A , Morrison , A C , Reiner , A P , Ridker , P M , Rotter , J I , Toniolo , D , Uitterlinden , A G , Ulivi , S , Völzke , H , Wareham , N J , Weir , D R , Yerges-Armstrong , L M , Price , A L , Stefansson , K , Visser , J A , Ong , K K , Chang-Claude , J , Murabito , J M M , Perry , J R B & Murray , A 2015 , ' Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair ' , Nature Genetics , vol. 47 , no. 11 , pp. 1294-1303 . https://doi.org/10.1038/ng.3412 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845365 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://research.vu.nl/en/publications/e822304f-31d5-4219-8380-be6c370b7cb1 |