Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify and replicate novel findings near ABO, ZC3HC1, and IGF2R. We also validate previous findings near 5q33.3/EBF1 and FOXO3, whilst finding contradictory evidence at other loci. Gene set and cell-specific analyses show that expression in foetal brain cells and adult dorsolateral prefrontal cortex is enriched for lifespan variation, as are gene pathways... Mehr ...
Verfasser: |
Timmers, Paul RHJ
Boomsma, D. I.
van Dongen, J.
Nivard, M. G.
Penninx, B.
Joshi, Peter K. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Timmers , P RHJ , Boomsma , D I , van Dongen , J , Nivard , M G , Penninx , B , Joshi , P K & eQTLGen Consortium 2019 , ' Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances ' , eLife , vol. 8 , e39856 , pp. 1-40 . https://doi.org/10.7554/eLife.39856 |
Schlagwörter: |
complex trait
/ genetics
/ genomics
/ human
/ lifespan
/ longevity
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845354 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/e6f2b298-4666-4698-9d52-d42fd47a822d |