A Genomewide Scan for Intelligence Identifies Quantitative Trait Loci on 2q and 6p
Between 40% and 80% of the variation in human intelligence (IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism.... Mehr ...
Verfasser: |
Posthuma, D.
Luciano, M.
de Geus, J.C.N.
Wright, M.J.
Slagboom, P.E.
Montgomery, GW
Boomsma, D.I.
Martin, N.G. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2005 |
Reihe/Periodikum: |
Posthuma , D , Luciano , M , de Geus , J C N , Wright , M J , Slagboom , P E , Montgomery , GW , Boomsma , D I & Martin , N G 2005 , ' A Genomewide Scan for Intelligence Identifies Quantitative Trait Loci on 2q and 6p ' , American Journal of Human Genetics , vol. 77 , no. 2 , pp. 318-326 . https://doi.org/10.1086/432647 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/quality_education
/ name=SDG 4 - Quality Education |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845341 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/e5975e8a-bdad-452e-a138-906a2975c753 |