Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Verfasser:	Justice, Anne E Winkler, Thomas W Feitosa, Mary F Graff, Misa Fisher, Virginia A Young, Kristin L Barata, Llilda Deng, Xuan Czajkowski, Jacek Hadley, David Ngwa, Julius S Ahluwalia, Tarunveer S Chu, Audrey Y Heard-Costa, Nancy L Lim, Elise Perez, Jeremiah Eicher, John D Kutalik, Zoltán Xue, Luting Mahajan, Anubha Renström, Frida Wu, Joseph Qi, Qibin Ahmad, Shafqat Alfred, Tamuno Amin, Najaf Bielak, Lawrence F Bonnefond, Amelie Bragg-Gresham, Jennifer L Cadby, Gemma Chittani, Martina Coggeshall, Scott Corre, Tanguy Direk, Nese Eriksson, Joel Fischer, Krista Gorski, Mathias Neergaard Harder, Marie Horikoshi, Momoko Huang, Tao Huffman, Jennifer E Jackson, Anne U Justesen, Johanne Marie Kanoni, Stavroula Kinnunen, Leena Kleber, Marcus E Komulainen, Pirjo Kumari, Meena Lim, Unhee Luan, Jian'an Lyytikäinen, Leo-Pekka Mangino, Massimo Manichaikul, Ani Marten, Jonathan Middelberg, Rita P S Müller-Nurasyid, Martina Navarro, Pau Pérusse, Louis Pervjakova, Natalia Sarti, Cinzia Smith, Albert Vernon Smith, Jennifer A Stančáková, Alena Strawbridge, Rona J Stringham, Heather M Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van der Most, Peter J van Vliet-Ostaptchouk, Jana V Vedantam, Sailaja L Verweij, Niek Vink, Jacqueline M Vitart, Veronique Wu, Ying Yengo, Loic Zhang, Weihua Hua Zhao, Jing Zimmermann, Martina E Zubair, Niha Abecasis, Gonçalo R Adair, Linda S Afaq, Saima Afzal, Uzma Bakker, Stephan J L Bartz, Traci M Beilby, John Bergman, Richard N Bergmann, Sven Biffar, Reiner Blangero, John Boerwinkle, Eric Bonnycastle, Lori L Bottinger, Erwin Braga, Daniele Buckley, Brendan M Buyske, Steve Campbell, Harry Chambers, John C Collins, Francis S Curran, Joanne E de Borst, Gert J De Craen, Anton J M de Geus, Eco J C Dedoussis, George Delgado, Graciela E den Ruijter, Hester M Eiriksdottir, Gudny Eriksson, Anna L Esko, Tõnu Faul, Jessica D Ford, Ian Forrester, Terrence Gertow, Karl Gigante, Bruna Glorioso, Nicola Gong, Jian Grallert, Harald Grammer, Tanja B Grarup, Niels Haitjema, Saskia Hallmans, Göran Hamsten, Anders Hansen, Torben Harris, Tamara B Hartman, Catharina A Hassinen, Maija Hastie, Nicholas D Heath, Andrew C Hernandez, Dena G Hindorff, Lucia Hocking, Lynne J Hollensted, Mette Holmen, Oddgeir L Homuth, Georg Huang, Jie Hung, Joseph Hutri-Kähönen, Nina Ingelsson, Erik James, Alan L Jansson, John-Olov Jarvelin, Marjo-Riitta Jhun, Min A Jørgensen, Marit E Juonala, Markus Kähönen, Mika Karlsson, Magnus Koistinen, Heikki A Kolcic, Ivana Kolovou, Genovefa Kooperberg, Charles Krämer, Bernhard K Kuusisto, Johanna Kvaløy, Kirsti Lakka, Timo A Langenberg, Claudia Launer, Lenore J Leander, Karin Lee, Nanette R Lind, Lars Lindgren, Cecilia M Linneberg, Allan Lobbens, Stephane Loh, Marie Lorentzon, Mattias Luben, Robert Lubke, Gitta Ludolph-Donislawski, Anja Lupoli, Sara Madden, Pamela A F Männikkö, Reija Marques-Vidal, Pedro M Martin, Nicholas G McKenzie, Colin A McKnight, Barbara Mellström, Dan Menni, Cristina Montgomery, Grant W Musk, Aw Bill Narisu, Narisu Nauck, Matthias Nolte, Ilja M Oldehinkel, Albertine J Olden, Matthias Ong, Ken K Padmanabhan, Sandosh Peyser, Patricia A Pisinger, Charlotta Porteous, David J Raitakari, Olli T Rankinen, Tuomo Rao, D.C. Rasmussen-Torvik, Laura J Rawal, Rajesh Rice, Treva Ridker, Paul M Rose, Lynda M Bien, Stephanie A Rudan, Igor Sanna, Serena Sarzynski, Mark A Sattar, Naveed Savonen, Kai Schlessinger, David Scholtens, Salome Schurmann, Claudia Scott, Robert A Sennblad, Bengt Siemelink, Marten A Silbernagel, Günther Slagboom, P. Eline Snieder, Harold Staessen, Jan A Stott, David J Swertz, Morris a. Swift, Amy J Taylor, Kent D Tayo, Bamidele O Thorand, Barbara Thuillier, Dorothee Tuomilehto, Jaakko Uitterlinden, Andre G Vandenput, Liesbeth Vohl, Marie-Claude Völzke, Henry Vonk, Judith M Waeber, Gérard Waldenberger, Melanie Westendorp, R.G.J. Wild, Sarah Willemsen, Gonneke Wolffenbuttel, Bruce H R Wong, Andrew Wright, Alan F Zhao, Wei Zillikens, M Carola Baldassarre, Damiano Balkau, Beverley Bandinelli, Stefania Böger, Carsten A Boomsma, Dorret I Bouchard, Claude Bruinenberg, Marcel Chasman, Daniel I Chen, Yii-DerIda Chines, Peter S Cooper, Richard S Cucca, Francesco Cusi, Daniele Faire, Ulf de Ferrucci, Luigi Franks, Paul W Froguel, Philippe Gordon-Larsen, Penny Grabe, Hans-Jörgen Gudnason, Vilmundur Haiman, Christopher A Hayward, Caroline Hveem, Kristian Johnson, Andrew D Wouter Jukema, J Kardia, Sharon L R Kivimaki, Mika Kooner, Jaspal S Kuh, Diana Laakso, Markku Lehtimäki, Terho Marchand, Loic Le März, Winfried McCarthy, Mark I Metspalu, Andres Morris, Andrew P Ohlsson, Claes Palmer, Lyle J Pasterkamp, Gerard Pedersen, Oluf Peters, Annette Peters, Ulrike Polasek, Ozren Psaty, Bruce M Qi, Lu Rauramaa, Rainer Smith, Blair H Sørensen, Thorkild I A Strauch, Konstantin Tiemeier, Henning Tremoli, Elena van der Harst, Pim Vestergaard, Henrik Vollenweider, Peter Wareham, Nicholas J Weir, David R Whitfield, John B Wilson, James F Tyrrell, Jessica Frayling, Timothy M Barroso, Inês Boehnke, Michael Deloukas, Panagiotis Fox, Caroline S Hirschhorn, Joel N Hunter, David J Spector, Tim D Strachan, David P van Duijn, Cornelia M Heid, Iris M Mohlke, Karen L Marchini, Jonathan Loos, Ruth J F Kilpeläinen, Tuomas O Liu, Ching-Ti Borecki, Ingrid B North, Kari E Cupples, L Adrienne Hottenga, J.J.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2017
Reihe/Periodikum:	Justice , A E , Winkler , T W , Feitosa , M F , Graff , M , Fisher , V A , Young , K L , Barata , L , Deng , X , Czajkowski , J , Hadley , D , Ngwa , J S , Ahluwalia , T S , Chu , A Y , Heard-Costa , N L , Lim , E , Perez , J , Eicher , J D , Kutalik , Z , Xue , L , Mahajan , A , Renström , F , Wu , J , Qi , Q , Ahmad , S , Alfred , T , Amin , N , Bielak , L F , Bonnefond , A , Bragg-Gresham , J L , Cadby , G , Chittani , M , Coggeshall , S , Corre , T , Direk , N , Eriksson , J , Fischer , K , Gorski , M , Neergaard Harder , M , Horikoshi , M , Huang , T , Huffman , J E , Jackson , A U , Justesen , J M , Kanoni , S , Kinnunen , L , Kleber , M E , Komulainen , P , Kumari , M , Lim , U , Luan , J , Lyytikäinen , L-P , Mangino , M , Manichaikul , A , Marten , J , Middelberg , R P S , Müller-Nurasyid , M , Navarro , P , Pérusse , L , Pervjakova , N , Sarti , C , Smith , A V , Smith , J A , Stančáková , A , Strawbridge , R J , Stringham , H M , Sung , Y J , Tanaka , T , Teumer , A , Trompet , S , van der Laan , S W , van der Most , P J , van Vliet-Ostaptchouk , J V , Vedantam , S L , Verweij , N , Vink , J M , Vitart , V , Wu , Y , Yengo , L , Zhang , W , Hua Zhao , J , Zimmermann , M E , Zubair , N , Abecasis , G R , Adair , L S , Afaq , S , Afzal , U , Bakker , S J L , Bartz , T M , Beilby , J , Bergman , R N , Bergmann , S , Biffar , R , Blangero , J , Boerwinkle , E , Bonnycastle , L L , Bottinger , E , Braga , D , Buckley , B M , Buyske , S , Campbell , H , Chambers , J C , Collins , F S , Curran , J E , de Borst , G J , De Craen , A J M , de Geus , E J C , Dedoussis , G , Delgado , G E , den Ruijter , H M , Eiriksdottir , G , Eriksson , A L , Esko , T , Faul , J D , Ford , I , Forrester , T , Gertow , K , Gigante , B , Glorioso , N , Gong , J , Grallert , H , Grammer , T B , Grarup , N , Haitjema , S , Hallmans , G , Hamsten , A , Hansen , T , Harris , T B , Hartman , C A , Hassinen , M , Hastie , N D , Heath , A C , Hernandez , D G , Hindorff , L , Hocking , L J , Hollensted , M , Holmen , O L , Homuth , G , Huang , J , Hung , J , Hutri-Kähönen , N , Ingelsson , E , James , A L , Jansson , J-O , Jarvelin , M-R , Jhun , M A , Jørgensen , M E , Juonala , M , Kähönen , M , Karlsson , M , Koistinen , H A , Kolcic , I , Kolovou , G , Kooperberg , C , Krämer , B K , Kuusisto , J , Kvaløy , K , Lakka , T A , Langenberg , C , Launer , L J , Leander , K , Lee , N R , Lind , L , Lindgren , C M , Linneberg , A , Lobbens , S , Loh , M , Lorentzon , M , Luben , R , Lubke , G , Ludolph-Donislawski , A , Lupoli , S , Madden , P A F , Männikkö , R , Marques-Vidal , P M , Martin , N G , McKenzie , C A , McKnight , B , Mellström , D , Menni , C , Montgomery , G W , Musk , A B , Narisu , N , Nauck , M , Nolte , I M , Oldehinkel , A J , Olden , M , Ong , K K , Padmanabhan , S , Peyser , P A , Pisinger , C , Porteous , D J , Raitakari , O T , Rankinen , T , Rao , D C , Rasmussen-Torvik , L J , Rawal , R , Rice , T , Ridker , P M , Rose , L M , Bien , S A , Rudan , I , Sanna , S , Sarzynski , M A , Sattar , N , Savonen , K , Schlessinger , D , Scholtens , S , Schurmann , C , Scott , R A , Sennblad , B , Siemelink , M A , Silbernagel , G , Slagboom , P E , Snieder , H , Staessen , J A , Stott , D J , Swertz , M A , Swift , A J , Taylor , K D , Tayo , B O , Thorand , B , Thuillier , D , Tuomilehto , J , Uitterlinden , A G , Vandenput , L , Vohl , M-C , Völzke , H , Vonk , J M , Waeber , G , Waldenberger , M , Westendorp , R G J , Wild , S , Willemsen , G , Wolffenbuttel , B H R , Wong , A , Wright , A F , Zhao , W , Zillikens , M C , Baldassarre , D , Balkau , B , Bandinelli , S , Böger , C A , Boomsma , D I , Bouchard , C , Bruinenberg , M , Chasman , D I , Chen , Y-D , Chines , P S , Cooper , R S , Cucca , F , Cusi , D , Faire , U D , Ferrucci , L , Franks , P W , Froguel , P , Gordon-Larsen , P , Grabe , H-J , Gudnason , V , Haiman , C A , Hayward , C , Hveem , K , Johnson , A D , Wouter Jukema , J , Kardia , S L R , Kivimaki , M , Kooner , J S , Kuh , D , Laakso , M , Lehtimäki , T , Marchand , L L , März , W , McCarthy , M I , Metspalu , A , Morris , A P , Ohlsson , C , Palmer , L J , Pasterkamp , G , Pedersen , O , Peters , A , Peters , U , Polasek , O , Psaty , B M , Qi , L , Rauramaa , R , Smith , B H , Sørensen , T I A , Strauch , K , Tiemeier , H , Tremoli , E , van der Harst , P , Vestergaard , H , Vollenweider , P , Wareham , N J , Weir , D R , Whitfield , J B , Wilson , J F , Tyrrell , J , Frayling , T M , Barroso , I , Boehnke , M , Deloukas , P , Fox , C S , Hirschhorn , J N , Hunter , D J , Spector , T D , Strachan , D P , van Duijn , C M , Heid , I M , Mohlke , K L , Marchini , J , Loos , R J F , Kilpeläinen , T O , Liu , C-T , Borecki , I B , North , K E , Cupples , L A & Hottenga , J J 2017 , ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ' , Nature Communications , vol. 8 , 14977 , pp. 14977 . https://doi.org/10.1038/ncomms14977
Schlagwörter:	Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-26845311
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/e0fc5e12-575e-440d-95ef-db800338568e

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.