Brain activation during cognitive planning in twins discordant or concordant for obsessive–compulsive symptoms

Neuroimaging studies have indicated abnormalities in cortico-striatal- thalamo-cortical circuits in patients with obsessive-compulsive disorder compared with controls. However, there are inconsistencies between studies regarding the exact set of brain structures involved and the direction of anatomical and functional changes. These inconsistencies may reflect the differential impact of environmental and genetic risk factors for obsessive-compulsive disorder on different parts of the brain. To distinguish between functional brain changes underlying environmentally and genetically mediated obses... Mehr ...