Genetic Overlap Between Schizophrenia and Developmental Psychopathology:Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development

BACKGROUND: Several nonpsychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the etiology of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by correlated genetic risk factors. METHODS: Polygenic risk scores (PRS), reflecting an individual's genetic risk for schizophrenia, were constructed for 2588 children from the Netherlands Twin Register (NTR) and 6127 from the Avon Longitudinal Study of Parents And Children (ALSPAC). The association... Mehr ...

Verfasser: Nivard, Michel G
Gage, Suzanne H
Hottenga, Jouke J
van Beijsterveldt, Catharina E M
Abdellaoui, A.
Bartels, Meike
Baselmans, Bart M L
Ligthart, L.
Pourcain, Beate St
Boomsma, Dorret I
Munafò, Marcus R
Middeldorp, Christel M
Dokumenttyp: Artikel
Erscheinungsdatum: 2017
Reihe/Periodikum: Nivard , M G , Gage , S H , Hottenga , J J , van Beijsterveldt , C E M , Abdellaoui , A , Bartels , M , Baselmans , B M L , Ligthart , L , Pourcain , B S , Boomsma , D I , Munafò , M R & Middeldorp , C M 2017 , ' Genetic Overlap Between Schizophrenia and Developmental Psychopathology : Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development ' , Schizophrenia Bulletin , vol. 43 , no. 6 , pp. 1197-1207 . https://doi.org/10.1093/schbul/sbx031
Schlagwörter: Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26845285
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/dd5cc109-d930-43bd-addc-578a6d55c44b