A method to customize population-specific arrays for genome-wide association testing
As an example of optimizing population-specific genotyping assays using a whole-genome sequence reference set, we detail the approach that followed to design the Axiom-NL array which is characterized by an improved imputation backbone based on the Genome of the Netherlands (GoNL) reference sequence and, compared with earlier arrays, a more comprehensive inclusion of SNPs on chromosomes X, Y, and the mitochondria. Common variants on the array were selected to be compatible with the Illumina Psych Array and the Affymetrix UK Biobank Axiom array. About 3.5% of the array (23 977 markers) represent... Mehr ...
| Verfasser: |
Ehli, E.A.
Abdellaoui, A.
Fedko, I.O.
Grieser, C.
Nohzadeh-Malakshah, S.
Willemsen, G.
de Geus, E.J.C.
Boomsma, D.I.
Davies, G.E.
Hottenga, J.J. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Ehli , E A , Abdellaoui , A , Fedko , I O , Grieser , C , Nohzadeh-Malakshah , S , Willemsen , G , de Geus , E J C , Boomsma , D I , Davies , G E & Hottenga , J J 2017 , ' A method to customize population-specific arrays for genome-wide association testing ' , European Journal of Human Genetics , vol. 25 , no. 2 , pp. 267-270 . https://doi.org/10.1038/ejhg.2016.152 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities
/ name=SDG 10 - Reduced Inequalities |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845273 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/db6ae942-8f37-422d-9e34-74aa1aa5c334 |
