Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fe... Mehr ...
| Verfasser: |
Beaumont, Robin N
Warrington, Nicole M
Cavadino, Alana
Tyrrell, Jessica
Nodzenski, Michael
Horikoshi, Momoko
Geller, Frank
Myhre, Ronny
Richmond, Rebecca C
Paternoster, Lavinia
Bradfield, Jonathan P
Kreiner-Møller, Eskil
Huikari, Ville
Metrustry, Sarah
Lunetta, Kathryn L
Painter, Jodie N
Hottenga, Jouke-Jan
Allard, Catherine
Barton, Sheila J
Espinosa, Ana
Marsh, Julie A
Potter, Catherine
Zhang, Ge
Ang, Wei
Berry, Diane J
Bouchard, Luigi
Das, Shikta
Hakonarson, Hakon
Heikkinen, Jani
Helgeland, Øyvind
Hocher, Berthold
Hofman, Albert
Inskip, Hazel M
Jones, Samuel E
Kogevinas, Manolis
Lind, Penelope A
Marullo, Letizia
Medland, Sarah E
Murray, Anna
Murray, Jeffrey C
Njølstad, Pål R
Nohr, Ellen A
Reichetzeder, Christoph
Ring, Susan M
Ruth, Katherine S
Santa-Marina, Loreto
Scholtens, Denise M
Willemsen, Gonneke
Bartels, Meike
Boomsma, Dorret I |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Beaumont , R N , Warrington , N M , Cavadino , A , Tyrrell , J , Nodzenski , M , Horikoshi , M , Geller , F , Myhre , R , Richmond , R C , Paternoster , L , Bradfield , J P , Kreiner-Møller , E , Huikari , V , Metrustry , S , Lunetta , K L , Painter , J N , Hottenga , J-J , Allard , C , Barton , S J , Espinosa , A , Marsh , J A , Potter , C , Zhang , G , Ang , W , Berry , D J , Bouchard , L , Das , S , Hakonarson , H , Heikkinen , J , Helgeland , Ø , Hocher , B , Hofman , A , Inskip , H M , Jones , S E , Kogevinas , M , Lind , P A , Marullo , L , Medland , S E , Murray , A , Murray , J C , Njølstad , P R , Nohr , E A , Reichetzeder , C , Ring , S M , Ruth , K S , Santa-Marina , L , Scholtens , D M , Willemsen , G , Bartels , M , Boomsma , D I & Early Growth Genetics (EGG) Consortium 2018 , ' Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics ' , Human Molecular Genetics , vol. 27 , no. 4 , ddx429 , pp. 742-756 . https://doi.org/10.1093/hmg/ddx429 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845228 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/d5b8f371-5a56-4f00-adbd-bd89cba2a034 |
