Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders 1 . They are heritable 2,3 and etiologically related 4,5 behaviors that have been resistant to gene discovery efforts 6–11 . In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol us... Mehr ...
Verfasser: |
Liu, Mengzhen
Hottenga, Jouke Jan
Jansen, Philip R.
Willemsen, Gonneke
Boomsma, Dorret I.
Davies, Gareth E.
Polderman, Tinca J.C.
Posthuma, Danielle
Vrieze, Scott |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Liu , M , Hottenga , J J , Jansen , P R , Willemsen , G , Boomsma , D I , Davies , G E , Polderman , T J C , Posthuma , D , Vrieze , S , 23Andme Research Team & HUNT All-In Psychiatry 2019 , ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ' , Nature Genetics , vol. 51 , no. 2 , pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845220 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/d4f99f77-96f4-405e-bbd0-77e4e9dde885 |