Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust... Mehr ...
| Verfasser: |
Perry, J.R.B.
Day, F.R.
Elks, C.E.
Sulem, P.
Thompson, D.J.
Ferreira, T.
He, C.
Chasman, D.I.
Esko, T.
Thorleifsson, G.
Albrecht, E.
Ang, W.Q.
Corre, T.
Cousminer, D.L.
Feenstra, B.
Franceschini, N.
Ganna, A.
Johnson, A.D.
Kjellqvist, S.
Lunetta, K.L.
McMahon, G.
Nolte, I.M.
Paternoster, L.
Porcu, E.
Smith, A.V.
Stolk, L.
Teumer, A.
Tsernikova, N.
Tikkanen, E.
Ulivi, S.
Wagner, E.K.
Amin, N.
Bierut, L.J.
Byrne, E.M.
Hottenga, J.J.
Koller, D.L.
Mangino, M.
Pers, T.H.
Yerges-Armstrong, L.M.
Zhao, J.H.
Andrulis, I.L.
Anton-Culver, H.
Atsma, F.
Bandinelli, S.
Beckmann, M.W.
Benitez, J.
Blomqvist, C.
Bojesen, S.E.
Bolla, M.K.
Bonanni, B.
Brauch, H.
Brenner, H.
Buring, J.E.
Chang-Claude, J.
Chanock, S.
Chen, J.
Chenevix-Trench, G.
Collee, J.M.
Couch, F.J.
Couper, D.
Coviello, A.D.
Cox, A.
Czene, K.
Pio d'Adamo, A.
Smith, G.D.
De Vivo, I.
Demerath, E.W.
Dennis, J.
Devilee, P.
Dieffenbach, A.K.
Dunning, A.M.
Eiriksdottir, G.
Eriksson, J.G.
Fasching, P.A.
Ferrucci, L.
Flesch-Janys, D.
Flyger, H.
Foroud, T.
Franke, L.
Garcia, M.E.
Garcia-Closas, M.
Geller, F.
de Geus, E.J.C.
Giles, G.G.
Gudbjartsson, D.F.
Gudnason, V.
Guenel, P.
Guo, S.
Hall, P.
Hamann, U.
Haring, R.
Hartman, C.A.
Heath, A.C.
Hofman, A.
Hooning, M.J.
Hopper, J.L.
Hu, F.B.
Hunter, D.J.
Karasik, D.
Kiel, D.P.
Knight, J.A.
Kosma, V.M.
Kutalik, Z.
Lai, S.
Lambrechts, D.
Lindblom, A.
Mägi, R.
Magnusson, P.K.
Mannermaa, A.
Martin, N.G.
Masson, G.
McArdle, P.F.
McArdle, W.L.
Melbye, M.
Michailidou, K.
Mihailov, E.
Milani, L.
Milne, R.L.
Nevanlinna, H.
Neven, P.
Nohr, E.A.
Oldehinkel, A.J.
Oostra, B.A.
Palotie, A.
Peacock, M.
Pedersen, N.L.
Peterlongo, P.
Peto, J.
Pharoah, P.D.P.
Postma, D.S.
Pouta, A.
Pylkäs, K.
Radice, P.
Ring, S.
Rivadeneira, F.
Robino, A.
Rose, L.M.
Rudolph, A.
Salomaa, V.
Sanna, S.
Schlessinger, D.
Schmidt, M.K.
Southey, M.C.
Sovio, U.
Stampfer, M.J.
Stöckl, D.
Storniolo, A.M.
Timpson, N.J.
Tyrer, J.
Visser, J.A.
Vollenweider, P.
Völzke, H.
Waeber, G.
Waldenberger, M.
Wallaschofski, H.
Wang, Q.
Willemsen, G.
Winqvist, R.
Wolffenbuttel, B.H.R.
Wright, M.J.
Boomsma, D.I.
Econs, M.J.
Khaw, K.T.
Loos, R.J.F.
McCarthy, M.I.
Montgomery, G.W.
Rice, J.P.
Streeten, E.A.
Thorsteinsdottir, U.
van Duijn, C.M.
Alizadeh, BZ
Bergmann, S.
Boerwinkle, E.
Boyd, H.A.
Crisponi, L.
Gasparini, P.
Gieger, C.
Harris, T.B.
Ingelsson, E.
Järvelin, M.R.
Kraft, P.
Lawlor, D.
Metspalu, A.
Pennell, C.E.
Ridker, P.M.
Snieder, H.
Sorensen, T.I.A.
Spector, T.D.
Strachan, D.P.
Uitterlinden, A.G.
Wareham, N.J.
Widen, E.
Zygmunt, M.
Murray, A.
Easton, D.F.
Stefansson, K.
Murabito, J.M.
Ong, K.K. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2014 |
| Reihe/Periodikum: |
Perry , J R B , Day , F R , Elks , C E , Sulem , P , Thompson , D J , Ferreira , T , He , C , Chasman , D I , Esko , T , Thorleifsson , G , Albrecht , E , Ang , W Q , Corre , T , Cousminer , D L , Feenstra , B , Franceschini , N , Ganna , A , Johnson , A D , Kjellqvist , S , Lunetta , K L , McMahon , G , Nolte , I M , Paternoster , L , Porcu , E , Smith , A V , Stolk , L , Teumer , A , Tsernikova , N , Tikkanen , E , Ulivi , S , Wagner , E K , Amin , N , Bierut , L J , Byrne , E M , Hottenga , J J , Koller , D L , Mangino , M , Pers , T H , Yerges-Armstrong , L M , Zhao , J H , Andrulis , I L , Anton-Culver , H , Atsma , F , Bandinelli , S , Beckmann , M W , Benitez , J , Blomqvist , C , Bojesen , S E , Bolla , M K , Bonanni , B , Brauch , H , Brenner , H , Buring , J E , Chang-Claude , J , Chanock , S , Chen , J , Chenevix-Trench , G , Collee , J M , Couch , F J , Couper , D , Coviello , A D , Cox , A , Czene , K , Pio d'Adamo , A , Smith , G D , De Vivo , I , Demerath , E W , Dennis , J , Devilee , P , Dieffenbach , A K , Dunning , A M , Eiriksdottir , G , Eriksson , J G , Fasching , P A , Ferrucci , L , Flesch-Janys , D , Flyger , H , Foroud , T , Franke , L , Garcia , M E , Garcia-Closas , M , Geller , F , de Geus , E J C , Giles , G G , Gudbjartsson , D F , Gudnason , V , Guenel , P , Guo , S , Hall , P , Hamann , U , Haring , R , Hartman , C A , Heath , A C , Hofman , A , Hooning , M J , Hopper , J L , Hu , F B , Hunter , D J , Karasik , D , Kiel , D P , Knight , J A , Kosma , V M , Kutalik , Z , Lai , S , Lambrechts , D , Lindblom , A , Mägi , R , Magnusson , P K , Mannermaa , A , Martin , N G , Masson , G , McArdle , P F , McArdle , W L , Melbye , M , Michailidou , K , Mihailov , E , Milani , L , Milne , R L , Nevanlinna , H , Neven , P , Nohr , E A , Oldehinkel , A J , Oostra , B A , Palotie , A , Peacock , M , Pedersen , N L , Peterlongo , P , Peto , J , Pharoah , P D P , Postma , D S , Pouta , A , Pylkäs , K , Radice , P , Ring , S , Rivadeneira , F , Robino , A , Rose , L M , Rudolph , A , Salomaa , V , Sanna , S , Schlessinger , D , Schmidt , M K , Southey , M C , Sovio , U , Stampfer , M J , Stöckl , D , Storniolo , A M , Timpson , N J , Tyrer , J , Visser , J A , Vollenweider , P , Völzke , H , Waeber , G , Waldenberger , M , Wallaschofski , H , Wang , Q , Willemsen , G , Winqvist , R , Wolffenbuttel , B H R , Wright , M J , Boomsma , D I , Econs , M J , Khaw , K T , Loos , R J F , McCarthy , M I , Montgomery , G W , Rice , J P , Streeten , E A , Thorsteinsdottir , U , van Duijn , C M , Alizadeh , BZ , Bergmann , S , Boerwinkle , E , Boyd , H A , Crisponi , L , Gasparini , P , Gieger , C , Harris , T B , Ingelsson , E , Järvelin , M R , Kraft , P , Lawlor , D , Metspalu , A , Pennell , C E , Ridker , P M , Snieder , H , Sorensen , T I A , Spector , T D , Strachan , D P , Uitterlinden , A G , Wareham , N J , Widen , E , Zygmunt , M , Murray , A , Easton , D F , Stefansson , K , Murabito , J M & Ong , K K 2014 , ' Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche ' , Nature , vol. 514 , no. 7520 , pp. 92-97 . https://doi.org/10.1038/nature13545 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845152 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/cb8b7c99-b1db-4447-9d07-92dff7b3ec00 |
