African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci... Mehr ...
| Verfasser: |
Palmer, N.D.
McDonough, C.W.
Hicks, P.J.
Roh, B.H.
Wing, M.R.
Sandy An, S.
Hester, J.M.
Cooke, J.N.
Bostrom, M.A.
Rudock, M.E.
Talbert, M.E.
Lewis, J.P.
Hottenga, J.J.
de Geus, E.J.C.
Willemsen, G.
Boomsma, D.I.
Ferrara, A.
Lu, L.
Ziegler, J.T.
Sale, M.M.
Divers, J.
Shriner, D.
Adeyemo, A.
Rotimi, C.N.
Ng, M.C.Y.
Langefeld, C.D.
Freedman, B.I.
Bowden, D.W.
Posthuma, D.
Penninx, B.W.J.H.
Sladek, R. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2012 |
| Reihe/Periodikum: |
Palmer , N D , McDonough , C W , Hicks , P J , Roh , B H , Wing , M R , Sandy An , S , Hester , J M , Cooke , J N , Bostrom , M A , Rudock , M E , Talbert , M E , Lewis , J P , Hottenga , J J , de Geus , E J C , Willemsen , G , Boomsma , D I , Ferrara , A , Lu , L , Ziegler , J T , Sale , M M , Divers , J , Shriner , D , Adeyemo , A , Rotimi , C N , Ng , M C Y , Langefeld , C D , Freedman , B I , Bowden , D W , Posthuma , D , Penninx , B W J H & Sladek , R 2012 , ' A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans ' , PLoS ONE , vol. 7 , no. 1 , e29202 , pp. e29202 . https://doi.org/10.1371/journal.pone.0029202 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845042 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/c05e6f17-de6e-4de5-9daf-94e3fb6ac780 |
