We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10
| Verfasser: |
Taylor, A.E.
Morris, R.W.
Fluharty, M.E.
Bjorngaard, J.H.
Asvold, B.O.
Gabrielsen, M.E.
Campbell, A.
Marioni, R.
Kumari, M.
Hällfors, J.
Männistö, S.
Marques-Vidal, P.
Kaakinen, M.
Cavadino, A.
Postmus, I.
Husemoen, L.L.N.
Skaaby, T.
Ahluwalia, T.S.
Treur, J.L.
Willemsen, G.
Dale, C.
Wannamethee, S.G.
Lahti, J.
Palotie, A.
Räikkönen, K.
Kisialiou, A.
McConnachie, A.
Padmanabhan, S.
Wong, A.
Dalgard, C.
Paternoster, L.
Ben-Shlomo, Y.
Tyrrell, J.
Horwood, L.J.
Fergusson, D.
Kennedy, M.A.
Frayling, T.M.
Nohr, E.A.
Christiansen, L.
Ohm Kyvik, K.
Kuh, D
Watt, G.
Eriksson, J.
Whincup, P.H.
Vink, J.M.
Boomsma, D.I.
Davey Smith, G.
Lawlor, D.
Linneberg, A.
Ford, I.
Jukema, J.W.
Power, C.
Hyppönen, E.
Järvelin, M.R.
Preisig, M.
Borodulin, K.
Kaprio, J.
Kivimaki, M.
Smith, B.H.
Hayward, C.
Romundstad, P.R.
Sørensen, T.I.A.
Munafo, M.R.
Sattar, N. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2014 |
| Reihe/Periodikum: |
Taylor , A E , Morris , R W , Fluharty , M E , Bjorngaard , J H , Asvold , B O , Gabrielsen , M E , Campbell , A , Marioni , R , Kumari , M , Hällfors , J , Männistö , S , Marques-Vidal , P , Kaakinen , M , Cavadino , A , Postmus , I , Husemoen , L L N , Skaaby , T , Ahluwalia , T S , Treur , J L , Willemsen , G , Dale , C , Wannamethee , S G , Lahti , J , Palotie , A , Räikkönen , K , Kisialiou , A , McConnachie , A , Padmanabhan , S , Wong , A , Dalgard , C , Paternoster , L , Ben-Shlomo , Y , Tyrrell , J , Horwood , L J , Fergusson , D , Kennedy , M A , Frayling , T M , Nohr , E A , Christiansen , L , Ohm Kyvik , K , Kuh , D , Watt , G , Eriksson , J , Whincup , P H , Vink , J M , Boomsma , D I , Davey Smith , G , Lawlor , D , Linneberg , A , Ford , I , Jukema , J W , Power , C , Hyppönen , E , Järvelin , M R , Preisig , M , Borodulin , K , Kaprio , J , Kivimaki , M , Smith , B H , Hayward , C , Romundstad , P R , Sørensen , T I A , Munafo , M R & Sattar , N 2014 , ' Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers ' , PLoS Genetics , vol. 10 , no. 12 , e1004799 . https://doi.org/10.1371/journal.pgen.1004799 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845033 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/bfce8451-369d-41f9-aaab-e69a567ad89b |
