Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug-metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 drug-metabolite associations after evaluation of confounders including co-treatment. We show that the... Mehr ...
| Verfasser: |
Liu, Jun
Lahousse, Lies
Nivard, Michel G
Bot, Mariska
Chen, Lianmin
van Klinken, Jan Bert
Thesing, Carisha S
Beekman, Marian
van den Akker, Erik Ben
Slieker, Roderick C
Waterham, Eveline
van der Kallen, Carla J H
de Boer, Irene
Li-Gao, Ruifang
Vojinovic, Dina
Amin, Najaf
Radjabzadeh, Djawad
Kraaij, Robert
Alferink, Louise J M
Murad, Sarwa Darwish
Uitterlinden, André G
Willemsen, Gonneke
Pool, Rene
Milaneschi, Yuri
van Heemst, Diana
Suchiman, H Eka D
Rutters, Femke
Elders, Petra J M
Beulens, Joline W J
van der Heijden, Amber A W A
van Greevenbroek, Marleen M J
Arts, Ilja C W
Onderwater, Gerrit L J
van den Maagdenberg, Arn M J M
Mook-Kanamori, Dennis O
Hankemeier, Thomas
Terwindt, Gisela M
Stehouwer, Coen D A
Geleijnse, Johanna M
't Hart, Leen M
Slagboom, P Eline
van Dijk, Ko Willems
Zhernakova, Alexandra
Fu, Jingyuan
Penninx, Brenda W J H
Boomsma, Dorret I
Demirkan, Ayşe
Stricker, Bruno H C
van Duijn, Cornelia M |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2020 |
| Reihe/Periodikum: |
Liu , J , Lahousse , L , Nivard , M G , Bot , M , Chen , L , van Klinken , J B , Thesing , C S , Beekman , M , van den Akker , E B , Slieker , R C , Waterham , E , van der Kallen , C J H , de Boer , I , Li-Gao , R , Vojinovic , D , Amin , N , Radjabzadeh , D , Kraaij , R , Alferink , L J M , Murad , S D , Uitterlinden , A G , Willemsen , G , Pool , R , Milaneschi , Y , van Heemst , D , Suchiman , H E D , Rutters , F , Elders , P J M , Beulens , J W J , van der Heijden , A A W A , van Greevenbroek , M M J , Arts , I C W , Onderwater , G L J , van den Maagdenberg , A M J M , Mook-Kanamori , D O , Hankemeier , T , Terwindt , G M , Stehouwer , C D A , Geleijnse , J M , 't Hart , L M , Slagboom , P E , van Dijk , K W , Zhernakova , A , Fu , J , Penninx , B W J H , Boomsma , D I , Demirkan , A , Stricker , B H C & van Duijn , C M 2020 , ' Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas ' , Nature Medicine , vol. 26 , no. 1 , pp. 110-117 . https://doi.org/10.1038/s41591-019-0722-x |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844925 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/b383856d-8f21-481c-a5c3-00327d7fbe4d |
