Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three g... Mehr ...
Verfasser: |
Lee, Phil H
Nivard, Michel G.
Posthuma, Danielle
Derks, E.M.
op Landt Slof, M.C.T.
Boomsma, D.I.
de Geus, Eco J.C.
Hottenga, Jouke Jan
Mbarek, Hamdi
Middeldorp, C.M.
W J H Penninx, Brenda
Cath, Danielle C
Denys, Damiaan
Neale, Benjamin M
Smoller, Jordan W |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Cross-Disorder Group of the Psychiatric Genomics Consortium , Lee , P H , Nivard , M G , Posthuma , D , Derks , E M , op Landt Slof , M C T , Boomsma , D I , de Geus , E J C , Hottenga , J J , Mbarek , H , Middeldorp , C M , W J H Penninx , B , Cath , D C , Denys , D , Neale , B M & Smoller , J W 2019 , ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ' , Cell , vol. 179 , no. 7 , pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020 |
Schlagwörter: |
cross-disorder genetics
/ functional genomics
/ gene expression
/ genetic architecture
/ genetic correlation
/ GWAS
/ neurodevelopment
/ pleiotropy
/ psychiatric disorders
/ Psychiatric genetics
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26844885 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/addab748-d56b-4f3f-8134-5a9db4d80a22 |