The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory... Mehr ...
| Verfasser: |
Hägg, S.
Zhan, Y
Karlsson, R.
Gerritsen, L.
Ploner, A.
Lee, J.-S.
Broer, L.
Deelen, J.
Marioni, Riccardo E
Wong, A
Lundquist, A
Zhu, G.
Hansell, Narelle K
Sillanpää, E.
Fedko, I O
Amin, N A
Beekman, M
Craen, A.J.M.
Degerman, S
Harris, S E
Kan, K-J
Martin-Ruiz, C.
Montgomery, Grant W
Adolfsson, A N
Reynolds, C.A.
Samani, Nilesh J
Suchiman, H E D
Viljanen, A
von Zglinicki, T
Wright, Margaret J
Hottenga, J-J
Boomsma, D I
Rantanen, T.
Kaprio, J A
Nyholt, D R
Martin, Nicholas G
Nyberg, L.
Adolfsson, R
Kuh, D
Starr, J. M.
Deary, I. J.
Slagboom, P. Eline
van Duijn, Cornelia M
Codd, V.
Pedersen, Nancy L |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Hägg , S , Zhan , Y , Karlsson , R , Gerritsen , L , Ploner , A , Lee , J-S , Broer , L , Deelen , J , Marioni , R E , Wong , A , Lundquist , A , Zhu , G , Hansell , N K , Sillanpää , E , Fedko , I O , Amin , N A , Beekman , M , Craen , A J M , Degerman , S , Harris , S E , Kan , K-J , Martin-Ruiz , C , Montgomery , G W , Adolfsson , A N , Reynolds , C A , Samani , N J , Suchiman , H E D , Viljanen , A , von Zglinicki , T , Wright , M J , Hottenga , J-J , Boomsma , D I , Rantanen , T , Kaprio , J A , Nyholt , D R , Martin , N G , Nyberg , L , Adolfsson , R , Kuh , D , Starr , J M , Deary , I J , Slagboom , P E , van Duijn , C M , Codd , V , Pedersen , N L & NeuroCHARGE Cognitive Working Group 2017 , ' Short telomere length is associated with impaired cognitive performance in European ancestry cohorts ' , Translational Psychiatry , vol. 7 , no. 4 , e1100 , pp. e1100 . https://doi.org/10.1038/tp.2017.73 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844844 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/a9163a1d-bf28-40d9-997f-af5e9b21770c |
