Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking typically employ self-report phenotypes. However, precise biomarker phenotypes may afford greater statistical power and identify novel variants. Here we report the results of a GWAS meta-Analysis of levels of cotinine, the primary metabolite of nicotine, in 4,548 daily smokers of European ancestry. We identified a locus close to UGT2B10 at 4q13.2 (minimum p = 5.89 × 10 â'10 for rs114612145), which was consequently replicated. This variant is in high linkage disequilibrium with a known functional... Mehr ...
| Verfasser: |
Ware, J.J.
Chen, X.
Vink, J.M.
Loukola, A.
Minica, C.C.
Pool, R.
Milaneschi, Y.
Mangino, M.
Menni, C.
Chen, J.
Peterson, R.E.
Auro, K.
Lyytikäinen, L.P.
Wedenoja, J.
Stiby, A.I.
Hemani, G.
Willemsen, G.
Hottenga, J.J.
Korhonen, T.
Heliövaara, M.
Perola, M.
Rose, R.J.
Paternoster, L.
Timpson, N.
Wassenaar, C.A.
Zhu, A.Z.X.
Davey Smith, G.
Raitakari, O.T.
Lehtimäki, T.
Kähönen, M.
Koskinen, S.
Spector, T.D.
Penninx, B.W.J.H.
Salomaa, V.
Boomsma, D.I.
Tyndale, R.F.
Kaprio, J.
Munafò, M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
Ware , J J , Chen , X , Vink , J M , Loukola , A , Minica , C C , Pool , R , Milaneschi , Y , Mangino , M , Menni , C , Chen , J , Peterson , R E , Auro , K , Lyytikäinen , L P , Wedenoja , J , Stiby , A I , Hemani , G , Willemsen , G , Hottenga , J J , Korhonen , T , Heliövaara , M , Perola , M , Rose , R J , Paternoster , L , Timpson , N , Wassenaar , C A , Zhu , A Z X , Davey Smith , G , Raitakari , O T , Lehtimäki , T , Kähönen , M , Koskinen , S , Spector , T D , Penninx , B W J H , Salomaa , V , Boomsma , D I , Tyndale , R F , Kaprio , J & Munafò , M 2016 , ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ' , Scientific Reports , vol. 6 , no. 20092 , 20092 . https://doi.org/10.1038/srep20092 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844756 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/9ee844b6-aa6d-469d-9802-8ec94b87a2af |
