Telomere shortening has been associated with multiple age-related diseases such as cardiovascular disease, diabetes, and dementia. However, the biological mechanisms responsible for these associations remain largely unknown. In order to gain insight into the metabolic processes driving the association of leukocyte telomere length (LTL) with age-related diseases, we investigated the association between LTL and serum metabolite levels in 7,853 individuals from seven independent cohorts. LTL was determined by quantitative polymerase chain reaction and the levels of 131 serum metabolites were meas... Mehr ...
| Verfasser: |
van der Spek, Ashley
Broer, Linda
Draisma, Harmen H M
Pool, René
Albrecht, Eva
Beekman, Marian
Mangino, Massimo
Raag, Mait
Nyholt, Dale R
Dharuri, Harish K
Codd, Veryan
Amin, Najaf
de Geus, Eco J C
Deelen, Joris
Demirkan, Ayse
Yet, Idil
Fischer, Krista
Haller, Toomas
Henders, Anjali K
Isaacs, Aaron
Medland, Sarah E
Montgomery, Grant W
Mooijaart, Simon P
Strauch, Konstantin
Suchiman, H Eka D
Vaarhorst, Anika A M
van Heemst, Diana
Wang-Sattler, Rui
Whitfield, John B
Willemsen, Gonneke
Wright, Margaret J
Martin, Nicholas G
Samani, Nilesh J
Metspalu, Andres
Eline Slagboom, P
Spector, Tim D
Boomsma, D.I.
van Duijn, Cornelia M
Gieger, Christian |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Reihe/Periodikum: |
van der Spek , A , Broer , L , Draisma , H H M , Pool , R , Albrecht , E , Beekman , M , Mangino , M , Raag , M , Nyholt , D R , Dharuri , H K , Codd , V , Amin , N , de Geus , E J C , Deelen , J , Demirkan , A , Yet , I , Fischer , K , Haller , T , Henders , A K , Isaacs , A , Medland , S E , Montgomery , G W , Mooijaart , S P , Strauch , K , Suchiman , H E D , Vaarhorst , A A M , van Heemst , D , Wang-Sattler , R , Whitfield , J B , Willemsen , G , Wright , M J , Martin , N G , Samani , N J , Metspalu , A , Eline Slagboom , P , Spector , T D , Boomsma , D I , van Duijn , C M & Gieger , C 2019 , ' Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length : the ENGAGE consortium ' , Scientific Reports , vol. 9 , no. 1 , 11623 , pp. 11623 . https://doi.org/10.1038/s41598-019-47282-6 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844749 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/9e7ccc83-4b2c-424c-93cf-6058c4d0d925 |
