Common variants associated with plasma triglycerides and risk for coronary artery disease

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associatio... Mehr ...

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Verfasser: Do, R.
Willer, C.J.
Schmidt, E.M.
Sengupta, S.
Gao, C.
Peloso, G.M.
Gustafsson, S.
Kanoni, S.
Ganna, A.
Chen, J.
Buchkovich, M.L.
Mora, S.
Beckmann, J.S.
Bragg-Gresham, J.L.
Chang, H.Y.
Demirkan, A.
den Hertog, H.M.
Donnelly, L.A.
Ehret, G.B.
Esko, T.
Feitosa, M.F.
Ferreira, T.
Fischer, K.
Fontanillas, P.
Fraser, R.M.
Freitag, D.F.
Gurdasani, D.
Heikkilä, K.
Hyppönen, E.
Isaacs, A.
Jackson, A.U.
Johansson, A.
Johnson, T.
Kaakinen, M.
Kettunen, J.
Kleber, M.E.
Li, X.
Luan, J.
Lyytikäinen, L.P.
Magnusson, P.K.
Mangino, M.
Mihailov, E.
Montasser, M.E.
Müller-Nurasyid, M.
Nolte, I.M.
O'Connell, J.R.
Palmer, C.D.
Perola, M.
Petersen, A.K.
Sanna, S.
Saxena, R.
Service, S.K.
Shah, S.
Shungin, D.
Sidore, C.
Song, C.
Strawbridge, R.J.
Surakka, I.
Tanaka, T.
Teslovich, T.M.
Thorleifsson, G.
van den Herik, E.G.
Voight, B.F.
Volcik, K.A.
Waite, L.L.
Wong, A.
Wu, Y.
Zhang, W.
Absher, D.
Asiki, G.
Barroso, I.
Been, L.F.
Bolton, J.L.
Bonnycastle, L.L.
Brambilla, P.
Burnett, M.S.
Cesana, G.
Dimitriou, M.
Doney, A.S.F.
Döring, A.
Elliott, P.
Epstein, S.E.
Eyjolfsson, G.I.
Gigante, B.
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Grallert, H.
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Jones, M.R.
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Klopp, N.
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Kumari, M.
Langenberg, C.
Lehtimäki, T.
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Lindström, J.
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Mach, F.
McArdle, W.L.
Meisinger, C.
Mitchell, B.D.
Müller, G.
Nagaraja, R.
Narisu, N.
Nieminen, T.V.
Nsubuga, R.N.
Olafsson, I.
Ong, K.K.
Palotie, A.
Papamarkou, T.
Pomilla, C.
Pouta, A.
Rader, D.J.
Reilly, M.P.
Ridker, P.M.
Rivadeneira, F.
Rudan, I.
Ruokonen, A.
Samani, N.J.
Scharnagl, H.
Seeley, J.
Silander, K.
Stancakova, A.
Stirrups, K.
Swift, A.J.
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Uitterlinden, A.G.
van Pelt, L.J.
Vedantam, S.
Wainwright, N.W.
Wijmenga, C.
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Willemsen, G.
Wilsgaard, T.
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Bennett, F.
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Boomsma, D.I.
Borecki, I.B.
Bornstein, S.R.
Bovet, P.
Burnier, M.
Campbell, H.
Chakravarti, A.
Chambers, J.C.
Chen, Y.D.
Collins, F.S.
Cooper, R.S.
Danesh, J.
Dedoussis, G.
de Faire, U.
Feranil, A.B.
Ferrières, J.
Ferrucci, L.
Freimer, N.B.
Gieger, C.
Groop, L.C.
Gudnason, V.
Gyllensten, U.
Hamsten, A.
Harris, T.B.
Hingorani, A.D.
Hirschhorn, J.N.
Hofman, A.
Hovingh, K.G.
Hsiung, C.A.
Humphries, S.E.
Hunt, S.C.
Hveem, K.
Iribarren, C.
Järvelin, M.R.
Jula, A.
Kähönen, M.
Kaprio, J.
Kesäniemi, A.
Kivimaki, M.
Kooner, J.S.
Koudstaal, P.J.
Krauss, R.M.
Kuh, D
Kuusisto, J.
Kyvik, K.O.
Laakso, M.
Lakka, T.A.
Lind, L.
Lindgren, C.M.
Martin, N.G.
März, W.
McCarthy, M.I.
McKenzie, C.A.
Meneton, P.
Metspalu, A.
Moilanen, L.
Morris, A.D.
Munroe, P.B.
Njolstad, I.
Pedersen, N.L.
Power, C.
Pramstaller, P.P.
Price, J.F.
Psaty, B.M.
Quertermous, T.
Rauramaa, R.
Saleheen, D.
Salomaa, V.
Sanghera, D.K.
Saramies, J.
Schwarz, P.E.
Sheu, W.H.
Shuldiner, A.R.
Siegbahn, A.
Spector, T.D.
Stefansson, K.
Strachan, D.P.
Tayo, B.O.
Tremoli, E.
Tuomilehto, J.
Uusitupa, M.
van Duijn, C.M.
Vollenweider, P.
Wallentin, L.
Wareham, N.J.
Whitfield, J.B.
Wolffenbuttel, B.H.
Altshuler, D.
Ordovas, J. M.
Boerwinkle, E.
Palmer, C.N.
Thorsteinsdottir, U.
Chasman, D.I.
Rotter, J.I.
Franks, P.W.
Ripatti, S.
Cupples, L.A.
Sandhu, M.S.
Rich, S.S.
Boehnke, M.
Deloukas, P.
Mohlke, K.L.
Ingelsson, E.
Abecasis, G.R.
Daly, M.J.
Neale, B.M.
Kathiresan, S.
Dokumenttyp: Artikel
Erscheinungsdatum: 2013
Reihe/Periodikum: Do , R , Willer , C J , Schmidt , E M , Sengupta , S , Gao , C , Peloso , G M , Gustafsson , S , Kanoni , S , Ganna , A , Chen , J , Buchkovich , M L , Mora , S , Beckmann , J S , Bragg-Gresham , J L , Chang , H Y , Demirkan , A , den Hertog , H M , Donnelly , L A , Ehret , G B , Esko , T , Feitosa , M F , Ferreira , T , Fischer , K , Fontanillas , P , Fraser , R M , Freitag , D F , Gurdasani , D , Heikkilä , K , Hyppönen , E , Isaacs , A , Jackson , A U , Johansson , A , Johnson , T , Kaakinen , M , Kettunen , J , Kleber , M E , Li , X , Luan , J , Lyytikäinen , L P , Magnusson , P K , Mangino , M , Mihailov , E , Montasser , M E , Müller-Nurasyid , M , Nolte , I M , O'Connell , J R , Palmer , C D , Perola , M , Petersen , A K , Sanna , S , Saxena , R , Service , S K , Shah , S , Shungin , D , Sidore , C , Song , C , Strawbridge , R J , Surakka , I , Tanaka , T , Teslovich , T M , Thorleifsson , G , van den Herik , E G , Voight , B F , Volcik , K A , Waite , L L , Wong , A , Wu , Y , Zhang , W , Absher , D , Asiki , G , Barroso , I , Been , L F , Bolton , J L , Bonnycastle , L L , Brambilla , P , Burnett , M S , Cesana , G , Dimitriou , M , Doney , A S F , Döring , A , Elliott , P , Epstein , S E , Eyjolfsson , G I , Gigante , B , Goodarzi , M O , Grallert , H , Gravito , M L , Groves , C J , Hallmans , G , Hartikainen , A L , Hayward , C , Hernandez , D , Hicks , A A , Holm , H , Hung , Y J , Illig , T , Jones , M R , Kaleebu , P , Kastelein , J J , Khaw , K T , Kim , E , Klopp , N , Komulainen , P , Kumari , M , Langenberg , C , Lehtimäki , T , Lin , S Y , Lindström , J , Loos , R J , Mach , F , McArdle , W L , Meisinger , C , Mitchell , B D , Müller , G , Nagaraja , R , Narisu , N , Nieminen , T V , Nsubuga , R N , Olafsson , I , Ong , K K , Palotie , A , Papamarkou , T , Pomilla , C , Pouta , A , Rader , D J , Reilly , M P , Ridker , P M , Rivadeneira , F , Rudan , I , Ruokonen , A , Samani , N J , Scharnagl , H , Seeley , J , Silander , K , Stancakova , A , Stirrups , K , Swift , A J , Tiret , L , Uitterlinden , A G , van Pelt , L J , Vedantam , S , Wainwright , N W , Wijmenga , C , Wild , S H , Willemsen , G , Wilsgaard , T , Wilson , J F , Young , E H , Zhao , J H , Adair , L S , Arveiler , D , Assimes , T L , Bandinelli , S , Bennett , F , Bochud , M , Boehm , B O , Boomsma , D I , Borecki , I B , Bornstein , S R , Bovet , P , Burnier , M , Campbell , H , Chakravarti , A , Chambers , J C , Chen , Y D , Collins , F S , Cooper , R S , Danesh , J , Dedoussis , G , de Faire , U , Feranil , A B , Ferrières , J , Ferrucci , L , Freimer , N B , Gieger , C , Groop , L C , Gudnason , V , Gyllensten , U , Hamsten , A , Harris , T B , Hingorani , A D , Hirschhorn , J N , Hofman , A , Hovingh , K G , Hsiung , C A , Humphries , S E , Hunt , S C , Hveem , K , Iribarren , C , Järvelin , M R , Jula , A , Kähönen , M , Kaprio , J , Kesäniemi , A , Kivimaki , M , Kooner , J S , Koudstaal , P J , Krauss , R M , Kuh , D , Kuusisto , J , Kyvik , K O , Laakso , M , Lakka , T A , Lind , L , Lindgren , C M , Martin , N G , März , W , McCarthy , M I , McKenzie , C A , Meneton , P , Metspalu , A , Moilanen , L , Morris , A D , Munroe , P B , Njolstad , I , Pedersen , N L , Power , C , Pramstaller , P P , Price , J F , Psaty , B M , Quertermous , T , Rauramaa , R , Saleheen , D , Salomaa , V , Sanghera , D K , Saramies , J , Schwarz , P E , Sheu , W H , Shuldiner , A R , Siegbahn , A , Spector , T D , Stefansson , K , Strachan , D P , Tayo , B O , Tremoli , E , Tuomilehto , J , Uusitupa , M , van Duijn , C M , Vollenweider , P , Wallentin , L , Wareham , N J , Whitfield , J B , Wolffenbuttel , B H , Altshuler , D , Ordovas , J M , Boerwinkle , E , Palmer , C N , Thorsteinsdottir , U , Chasman , D I , Rotter , J I , Franks , P W , Ripatti , S , Cupples , L A , Sandhu , M S , Rich , S S , Boehnke , M , Deloukas , P , Mohlke , K L , Ingelsson , E , Abecasis , G R , Daly , M J , Neale , B M & Kathiresan , S 2013 , ' Common variants associated with plasma triglycerides and risk for coronary artery disease ' , Nature Genetics , vol. 45 , no. 11 , pp. 1345-1352 . https://doi.org/10.1038/ng.2795
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26844354
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/856b9f12-43d2-44c2-8567-122f0b47a69e