Genome-wide Association Study of Smoking Initiation and Current Smoking

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) a... Mehr ...

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Verfasser: Vink, J.M.
Smit, A.B.
de Geus, E.J.C.
Sullivan, P.F.
Willemsen, G.
Hottenga, J.J.
Smit, J.H.
Hoogendijk, W.J.G.
Zitman, F. G.
Peltonen, L.
Kaprio, J.
Pedersen, N.L.
Magnusson, P.K.E.
Spector, T.D.
Kyvik, K.O.
Morley, K.I.
Heath, A.C.
Martin, N.G.
Westendorp, R.G.J.
Slagboom, P.E.
Tiemeier, H.
Hofman, A.
Uitterlinden, A.G.
Aulchenko, Y.S.
Amin, N.
van Duijn, C.
Penninx, B.W.J.H.
Boomsma, D.I.
Dokumenttyp: Artikel
Erscheinungsdatum: 2009
Reihe/Periodikum: Vink , J M , Smit , A B , de Geus , E J C , Sullivan , P F , Willemsen , G , Hottenga , J J , Smit , J H , Hoogendijk , W J G , Zitman , F G , Peltonen , L , Kaprio , J , Pedersen , N L , Magnusson , P K E , Spector , T D , Kyvik , K O , Morley , K I , Heath , A C , Martin , N G , Westendorp , R G J , Slagboom , P E , Tiemeier , H , Hofman , A , Uitterlinden , A G , Aulchenko , Y S , Amin , N , van Duijn , C , Penninx , B W J H & Boomsma , D I 2009 , ' Genome-wide Association Study of Smoking Initiation and Current Smoking ' , American Journal of Human Genetics , vol. 84 , no. 3 , pp. 367-379 . https://doi.org/10.1016/j.ajhg.2009.02.001
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26844251
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/7a18145c-5f9e-4640-a1a4-9cc0b14aef4a