Genetic and environmental influences interact with age and sex in shaping the human methylome

The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex-and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-s... Mehr ...

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Verfasser: van Dongen, J.
Nivard, M.G.
Willemsen, G.
Hottenga, J.J.
Helmer, Q.
Dolan, C.V.
Ehli, E.A.
Davies, G.E.
van Iterson, M.
Breeze, C.E.
Beck, S.
Pool, R.
Suchiman, H.E.D.
Jansen, R.
van Meurs, J.B.
Heijmans, B.T.
Slagboom, P.E.
Boomsma, D.I.
Dokumenttyp: Artikel
Erscheinungsdatum: 2016
Reihe/Periodikum: van Dongen , J , Nivard , M G , Willemsen , G , Hottenga , J J , Helmer , Q , Dolan , C V , Ehli , E A , Davies , G E , van Iterson , M , Breeze , C E , Beck , S , Pool , R , Suchiman , H E D , Jansen , R , van Meurs , J B , Heijmans , B T , Slagboom , P E & Boomsma , D I 2016 , ' Genetic and environmental influences interact with age and sex in shaping the human methylome ' , Nature Communications , vol. 7 , no. 11115 , 11115 , pp. 1-13 . https://doi.org/10.1038/ncomms11115
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26844245
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/7980d9cc-5372-4356-9bbd-faead77fe3b2