Genetic architecture of subcortical brain structures in 38,851 individuals

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data id... Mehr ...

Verfasser:	Satizabal, Claudia L Adams, Hieab H H Hibar, Derrek P White, Charles C Knol, Maria J Stein, Jason L Scholz, Markus Sargurupremraj, Muralidharan Jahanshad, Neda Roshchupkin, Gennady V Smith, Albert V Bis, Joshua C Jian, Xueqiu Luciano, Michelle Hofer, Edith Teumer, Alexander van der Lee, Sven J Yang, Jingyun Yanek, Lisa R Lee, Tom V Li, Shuo Hu, Yanhui Koh, Jia Yu Eicher, John D Desrivières, Sylvane Arias-Vasquez, Alejandro Chauhan, Ganesh Athanasiu, Lavinia Rentería, Miguel E Kim, Sungeun Hoehn, David Armstrong, Nicola J Chen, Qiang Holmes, Avram J den Braber, Anouk Kloszewska, Iwona Andersson, Micael Espeseth, Thomas Grimm, Oliver Abramovic, Lucija Alhusaini, Saud Milaneschi, Yuri Papmeyer, Martina Axelsson, Tomas Ehrlich, Stefan Roiz-Santiañez, Roberto Kraemer, Bernd Håberg, Asta K Jones, Hannah J Pike, G Bruce Stein, Dan J Stevens, Allison Bralten, Janita Vernooij, Meike W Harris, Tamara B Filippi, Irina Witte, A Veronica Guadalupe, Tulio Wittfeld, Katharina Mosley, Thomas H Becker, James T Doan, Nhat Trung Hagenaars, Saskia P Saba, Yasaman Cuellar-Partida, Gabriel Amin, Najaf Hilal, Saima Nho, Kwangsik Mirza-Schreiber, Nazanin Arfanakis, Konstantinos Becker, Diane M Ames, David Goldman, Aaron L Lee, Phil H Boomsma, Dorret I Lovestone, Simon Giddaluru, Sudheer Le Hellard, Stephanie Mattheisen, Manuel Bohlken, Marc M Kasperaviciute, Dalia Schmaal, Lianne Lawrie, Stephen M Agartz, Ingrid Walton, Esther Tordesillas-Gutierrez, Diana Davies, Gareth E Shin, Jean Ipser, Jonathan C Vinke, Louis N Hoogman, Martine Jia, Tianye Burkhardt, Ralph Klein, Marieke Crivello, Fabrice Janowitz, Deborah Carmichael, Owen Haukvik, Unn K Aribisala, Benjamin S Schmidt, Helena Strike, Lachlan T Cheng, Ching-Yu Risacher, Shannon L Pütz, Benno Fleischman, Debra A Assareh, Amelia A Mattay, Venkata S Buckner, Randy L Mecocci, Patrizia Dale, Anders M Cichon, Sven Boks, Marco P Matarin, Mar Penninx, Brenda W J H Calhoun, Vince D Chakravarty, M Mallar Marquand, Andre F Macare, Christine Kharabian Masouleh, Shahrzad Oosterlaan, Jaap Amouyel, Philippe Hegenscheid, Katrin Rotter, Jerome I Schork, Andrew J Liewald, David C M de Zubicaray, Greig I Wong, Tien Yin Shen, Li Sämann, Philipp G Brodaty, Henry Roffman, Joshua L de Geus, Eco J C Tsolaki, Magda Erk, Susanne van Eijk, Kristel R Cavalleri, Gianpiero L van der Wee, Nic J A McIntosh, Andrew M Gollub, Randy L Bulayeva, Kazima B Bernard, Manon Richards, Jennifer S Himali, Jayandra J Loeffler, Markus Rommelse, Nanda Hoffmann, Wolfgang Westlye, Lars T Valdés Hernández, Maria C Hansell, Narelle K van Erp, Theo G M Wolf, Christiane Kwok, John B J Vellas, Bruno Heinz, Andreas Olde Loohuis, Loes M Delanty, Norman Ho, Beng-Choon Ching, Christopher R K Shumskaya, Elena Singh, Baljeet Hofman, Albert van der Meer, Dennis Homuth, Georg Psaty, Bruce M Bastin, Mark E Montgomery, Grant W Foroud, Tatiana M Reppermund, Simone Hottenga, Jouke-Jan Simmons, Andrew Meyer-Lindenberg, Andreas Cahn, Wiepke Whelan, Christopher D van Donkelaar, Marjolein M J Yang, Qiong Hosten, Norbert Green, Robert C Thalamuthu, Anbupalam Mohnke, Sebastian Hulshoff Pol, Hilleke E Lin, Honghuang Jack, Clifford R Schofield, Peter R Mühleisen, Thomas W Maillard, Pauline Potkin, Steven G Wen, Wei Fletcher, Evan Toga, Arthur W Gruber, Oliver Huentelman, Matthew Davey Smith, George Launer, Lenore J Nyberg, Lars Jönsson, Erik G Crespo-Facorro, Benedicto Koen, Nastassja Greve, Douglas N Uitterlinden, André G Weinberger, Daniel R Steen, Vidar M Fedko, Iryna O Groenewold, Nynke A Niessen, Wiro J Toro, Roberto Tzourio, Christophe Longstreth, William T Ikram, M Kamran Smoller, Jordan W van Tol, Marie-Jose Sussmann, Jessika E Paus, Tomas Lemaître, Hervé Schroeter, Matthias L Mazoyer, Bernard Andreassen, Ole A Holsboer, Florian Depondt, Chantal Veltman, Dick J Turner, Jessica A Pausova, Zdenka Schumann, Gunter van Rooij, Daan Djurovic, Srdjan Deary, Ian J McMahon, Katie L Müller-Myhsok, Bertram Brouwer, Rachel M Soininen, Hilkka Pandolfo, Massimo Wassink, Thomas H Cheung, Joshua W Wolfers, Thomas Martinot, Jean-Luc Zwiers, Marcel P Nauck, Matthias Melle, Ingrid Martin, Nicholas G Kanai, Ryota Westman, Eric Kahn, René S Sisodiya, Sanjay M White, Tonya Saremi, Arvin van Bokhoven, Hans Brunner, Han G Völzke, Henry Wright, Margaret J van 't Ent, Dennis Nöthen, Markus M Ophoff, Roel A Buitelaar, Jan K Fernández, Guillén Sachdev, Perminder S Rietschel, Marcella van Haren, Neeltje E M Fisher, Simon E Beiser, Alexa S Francks, Clyde Saykin, Andrew J Mather, Karen A Romanczuk-Seiferth, Nina Hartman, Catharina A DeStefano, Anita L Heslenfeld, Dirk J Weiner, Michael W Walter, Henrik Hoekstra, Pieter J Nyquist, Paul A Franke, Barbara Bennett, David A Grabe, Hans J Johnson, Andrew D Chen, Christopher van Duijn, Cornelia M Lopez, Oscar L Fornage, Myriam Wardlaw, Joanna M Schmidt, Reinhold DeCarli, Charles De Jager, Philip L Villringer, Arno Debette, Stéphanie Gudnason, Vilmundur Medland, Sarah E Shulman, Joshua M Thompson, Paul M Seshadri, Sudha Ikram, M Arfan
Dokumenttyp:	Artikel
Erscheinungsdatum:	2019
Reihe/Periodikum:	Satizabal , C L , Adams , H H H , Hibar , D P , White , C C , Knol , M J , Stein , J L , Scholz , M , Sargurupremraj , M , Jahanshad , N , Roshchupkin , G V , Smith , A V , Bis , J C , Jian , X , Luciano , M , Hofer , E , Teumer , A , van der Lee , S J , Yang , J , Yanek , L R , Lee , T V , Li , S , Hu , Y , Koh , J Y , Eicher , J D , Desrivières , S , Arias-Vasquez , A , Chauhan , G , Athanasiu , L , Rentería , M E , Kim , S , Hoehn , D , Armstrong , N J , Chen , Q , Holmes , A J , den Braber , A , Kloszewska , I , Andersson , M , Espeseth , T , Grimm , O , Abramovic , L , Alhusaini , S , Milaneschi , Y , Papmeyer , M , Axelsson , T , Ehrlich , S , Roiz-Santiañez , R , Kraemer , B , Håberg , A K , Jones , H J , Pike , G B , Stein , D J , Stevens , A , Bralten , J , Vernooij , M W , Harris , T B , Filippi , I , Witte , A V , Guadalupe , T , Wittfeld , K , Mosley , T H , Becker , J T , Doan , N T , Hagenaars , S P , Saba , Y , Cuellar-Partida , G , Amin , N , Hilal , S , Nho , K , Mirza-Schreiber , N , Arfanakis , K , Becker , D M , Ames , D , Goldman , A L , Lee , P H , Boomsma , D I , Lovestone , S , Giddaluru , S , Le Hellard , S , Mattheisen , M , Bohlken , M M , Kasperaviciute , D , Schmaal , L , Lawrie , S M , Agartz , I , Walton , E , Tordesillas-Gutierrez , D , Davies , G E , Shin , J , Ipser , J C , Vinke , L N , Hoogman , M , Jia , T , Burkhardt , R , Klein , M , Crivello , F , Janowitz , D , Carmichael , O , Haukvik , U K , Aribisala , B S , Schmidt , H , Strike , L T , Cheng , C-Y , Risacher , S L , Pütz , B , Fleischman , D A , Assareh , A A , Mattay , V S , Buckner , R L , Mecocci , P , Dale , A M , Cichon , S , Boks , M P , Matarin , M , Penninx , B W J H , Calhoun , V D , Chakravarty , M M , Marquand , A F , Macare , C , Kharabian Masouleh , S , Oosterlaan , J , Amouyel , P , Hegenscheid , K , Rotter , J I , Schork , A J , Liewald , D C M , de Zubicaray , G I , Wong , T Y , Shen , L , Sämann , P G , Brodaty , H , Roffman , J L , de Geus , E J C , Tsolaki , M , Erk , S , van Eijk , K R , Cavalleri , G L , van der Wee , N J A , McIntosh , A M , Gollub , R L , Bulayeva , K B , Bernard , M , Richards , J S , Himali , J J , Loeffler , M , Rommelse , N , Hoffmann , W , Westlye , L T , Valdés Hernández , M C , Hansell , N K , van Erp , T G M , Wolf , C , Kwok , J B J , Vellas , B , Heinz , A , Olde Loohuis , L M , Delanty , N , Ho , B-C , Ching , C R K , Shumskaya , E , Singh , B , Hofman , A , van der Meer , D , Homuth , G , Psaty , B M , Bastin , M E , Montgomery , G W , Foroud , T M , Reppermund , S , Hottenga , J-J , Simmons , A , Meyer-Lindenberg , A , Cahn , W , Whelan , C D , van Donkelaar , M M J , Yang , Q , Hosten , N , Green , R C , Thalamuthu , A , Mohnke , S , Hulshoff Pol , H E , Lin , H , Jack , C R , Schofield , P R , Mühleisen , T W , Maillard , P , Potkin , S G , Wen , W , Fletcher , E , Toga , A W , Gruber , O , Huentelman , M , Davey Smith , G , Launer , L J , Nyberg , L , Jönsson , E G , Crespo-Facorro , B , Koen , N , Greve , D N , Uitterlinden , A G , Weinberger , D R , Steen , V M , Fedko , I O , Groenewold , N A , Niessen , W J , Toro , R , Tzourio , C , Longstreth , W T , Ikram , M K , Smoller , J W , van Tol , M-J , Sussmann , J E , Paus , T , Lemaître , H , Schroeter , M L , Mazoyer , B , Andreassen , O A , Holsboer , F , Depondt , C , Veltman , D J , Turner , J A , Pausova , Z , Schumann , G , van Rooij , D , Djurovic , S , Deary , I J , McMahon , K L , Müller-Myhsok , B , Brouwer , R M , Soininen , H , Pandolfo , M , Wassink , T H , Cheung , J W , Wolfers , T , Martinot , J-L , Zwiers , M P , Nauck , M , Melle , I , Martin , N G , Kanai , R , Westman , E , Kahn , R S , Sisodiya , S M , White , T , Saremi , A , van Bokhoven , H , Brunner , H G , Völzke , H , Wright , M J , van 't Ent , D , Nöthen , M M , Ophoff , R A , Buitelaar , J K , Fernández , G , Sachdev , P S , Rietschel , M , van Haren , N E M , Fisher , S E , Beiser , A S , Francks , C , Saykin , A J , Mather , K A , Romanczuk-Seiferth , N , Hartman , C A , DeStefano , A L , Heslenfeld , D J , Weiner , M W , Walter , H , Hoekstra , P J , Nyquist , P A , Franke , B , Bennett , D A , Grabe , H J , Johnson , A D , Chen , C , van Duijn , C M , Lopez , O L , Fornage , M , Wardlaw , J M , Schmidt , R , DeCarli , C , De Jager , P L , Villringer , A , Debette , S , Gudnason , V , Medland , S E , Shulman , J M , Thompson , P M , Seshadri , S & Ikram , M A 2019 , ' Genetic architecture of subcortical brain structures in 38,851 individuals ' , Nature Genetics , vol. 51 , no. 11 , pp. 1624-1636 . https://doi.org/10.1038/s41588-019-0511-y
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-26844235
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/78126867-921a-42a4-9782-e8522f6ba4d4

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