Many disease-associated variants affect gene expression levels (expression quantitative trait loci, eQTLs) and expression profiling using next generation sequencing (NGS) technology is a powerful way to detect these eQTLs. We analyzed 94 total blood samples from healthy volunteers with DeepSAGE to gain specific insight into how genetic variants affect the expression of genes and lengths of 3′-untranslated regions (3′-UTRs). We detected previously unknown cis-eQTL effects for GWAS hits in disease- and physiology-associated traits. Apart from cis-eQTLs that are typically easily identifiable usin... Mehr ...
Verfasser: |
Zhernakova, D.V.
de Klerk, E.D.
Westra, H.J.
Mastrokolias, A.
Amini, S.
Ariyurek, Y.
Jansen, R.
Penninx, B.W.J.H.
Hottenga, J.J.
Willemsen, G.
de Geus, E.J.C.
Boomsma, D.I.
Veldink, J.H.
Van den Berg, L.H.
Wijmenga, C.
den Dunnen, J.T.
van Ommen, G.J.B
't Hoen, P.A.C.
Franke, L |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Zhernakova , D V , de Klerk , E D , Westra , H J , Mastrokolias , A , Amini , S , Ariyurek , Y , Jansen , R , Penninx , B W J H , Hottenga , J J , Willemsen , G , de Geus , E J C , Boomsma , D I , Veldink , J H , Van den Berg , L H , Wijmenga , C , den Dunnen , J T , van Ommen , G J B , 't Hoen , P A C & Franke , L 2013 , ' DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts ' , PLoS Genetics , vol. 9 , no. 6 , e1003594 , pp. e1003594 . https://doi.org/10.1371/journal.pgen.1003594 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26844189 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/72259400-36ea-4b7e-ab63-80ac08b68a68 |