Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enr... Mehr ...
| Verfasser: |
Warren, Helen R
Evangelou, Evangelos
Cabrera, Claudia P
Gao, He
Ren, Meixia
Mifsud, Borbala
Ntalla, Ioanna
Surendran, Praveen
Liu, Chunyu
Cook, James P
Kraja, Aldi T
Drenos, Fotios
Loh, Marie
Verweij, Niek
Marten, Jonathan
Karaman, Ibrahim
Lepe, Marcelo P Segura
O'Reilly, Paul F
Knight, Joanne
Snieder, Harold
Kato, Norihiro
He, Jiang
Tai, E Shyong
Said, M Abdullah
Porteous, David
Alver, Maris
Poulter, Neil
Farrall, Martin
Gansevoort, Ron T
Padmanabhan, Sandosh
Mägi, Reedik
Stanton, Alice
Connell, John
Bakker, Stephan J L
Metspalu, Andres
Shields, Denis C
Thom, Simon
Brown, Morris
Sever, Peter
Esko, Tõnu
Hayward, Caroline
van der Harst, Pim
Saleheen, Danish
Chowdhury, Rajiv
Chambers, John C
Chasman, Daniel I
Hottenga, J.J.
de Geus, Eco
Willemsen, Gonneke
Boomsma, D.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Warren , H R , Evangelou , E , Cabrera , C P , Gao , H , Ren , M , Mifsud , B , Ntalla , I , Surendran , P , Liu , C , Cook , J P , Kraja , A T , Drenos , F , Loh , M , Verweij , N , Marten , J , Karaman , I , Lepe , M P S , O'Reilly , P F , Knight , J , Snieder , H , Kato , N , He , J , Tai , E S , Said , M A , Porteous , D , Alver , M , Poulter , N , Farrall , M , Gansevoort , R T , Padmanabhan , S , Mägi , R , Stanton , A , Connell , J , Bakker , S J L , Metspalu , A , Shields , D C , Thom , S , Brown , M , Sever , P , Esko , T , Hayward , C , van der Harst , P , Saleheen , D , Chowdhury , R , Chambers , J C , Chasman , D I , International Consortium of Blood Pressure (ICBP) 1000G Analyses , Hottenga , J J , de Geus , E , Willemsen , G & Boomsma , D I 2017 , ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ' , Nature Genetics , vol. 49 , no. 3 , pp. 403-415 . https://doi.org/10.1038/ng.3768 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844068 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
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https://research.vu.nl/en/publications/63a7249f-0e55-4cfc-9455-7505db70abc1 |
