Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10 -8, including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancest... Mehr ...
Verfasser: |
Willer, C.J.
Schmidt, E.M.
Sengupta, S.
Peloso, G.M.
Gustafsson, S.
Kanoni, S.
Ganna, A.
Chen, J.
Buchkovich, M.L.
Mora, S.
Beckmann, J.S.
Bragg-Gresham, J.L.
Chang, H.Y.
Demirkan, A.
den Hertog, H.M.
Do, R.
Donnelly, L.A.
Ehret, G.B.
Esko, T.
Feitosa, M.F.
Ferreira, T.
Fischer, K.
Fontanillas, P.
Fraser, R.M.
Freitag, D.F.
Gurdasani, D.
Heikkilä, K.
Hyppönen, E.
Isaacs, A.
Jackson, A.U.
Johansson, A.
Johnson, T.
Kaakinen, M.
Kettunen, J.
Kleber, M.E.
Li, X.
Luan, J.
Lyytikäinen, L.P.
Magnusson, P.K.
Mangino, M.
Mihailov, E.
Montasser, M.E.
Müller-Nurasyid, M.
Nolte, I.M.
O'Connell, J.R.
Palmer, C.D.
Perola, M.
Petersen, A.K.
Sanna, S.
Saxena, R.
Service, S.K.
Shah, S.
Shungin, D.
Sidore, C.
Song, C.
Strawbridge, R.J.
Surakka, I.
Tanaka, T.
Teslovich, T.M.
Thorleifson, G.
van den Herik, E.G.
Voight, B.F.
Volcik, K.A.
Waite, L.L.
Wong, A.
Wu, Y.
Zhang, W.
Absher, D.
Asiki, G.
Barroso, I.
Been, L.F.
Bolton, J.L.
Bonnycastle, L.L.
Brambilla, P.
Burnett, M.S.
Cesana, G.
Dimitriou, M.
Doney, A.S.F.
Döring, A.
Elliott, P.
Epstein, S.E.
Eyjolfsson, G.I.
Gigante, B.
Goodarzi, M.O.
Grallert, H.
Gravito, M.L.
Groves, C.J.
Hallmans, G.
Hartikainen, A.L.
Hayward, C.
Hernandez, D.
Hicks, A.A.
Holm, H.
Hung, Y.J.
Illig, T.
Jones, M.R.
Kaleebu, P.
Kastelein, J.J.
Khaw, K.T.
Kim, E.
Klopp, N.
Komulainen, P.
Kumari, M.
Langenberg, C.
Lehtimäki, T.
Lin, S.Y.
Lindström, J.
Loos, R.J.
Mach, F.
McArdle, W.L.
Meisinger, C.
Mitchell, B.D.
Müller, G.
Nagaraja, R.
Narisu, N.
Nieminen, T.V.
Nsubuga, R.N.
Olafsson, I.
Ong, K.K.
Palotie, A.
Papamarkou, T.
Pomilla, C.
Pouta, A.
Rader, D.J.
Reilly, M.P.
Ridker, P.M.
Rivadeneira, F.
Rudan, I.
Ruokonen, A.
Samani, N.J.
Scharnagl, H.
Seeley, J.
Silander, K.
Stancakova, A.
Stirrups, K.
Swift, A.J.
Tiret, L.
Uitterlinden, A.G.
van Pelt, L.J.
Vedantam, S.
Wainwright, N.W.
Wijmenga, C.
Wild, S.H.
Willemsen, G.
Wilsgaard, T.
Wilson, J.F.
Young, E.H.
Zhao, J.H.
Adair, L.S.
Arveiler, D.
Assimes, T.L.
Bandinelli, S.
Bennett, F.
Bochud, M.
Boehm, B.O.
Boomsma, D.I.
Borecki, I.B.
Bornstein, S.R.
Bovet, P.
Burnier, M.
Campbell, H.
Chakravarti, A.
Chambers, J.C.
Chen, Y.D.
Collins, F.S.
Cooper, R.S.
Danesh, J.
Dedoussis, G.
de Faire, U.
Feranil, A.B.
Ferrières, J.
Ferrucci, L.
Freimer, N.B.
Gieger, C.
Groop, L.C.
Gudnason, V.
Gyllensten, U.
Hamsten, A.
Harris, T.B.
Hingorani, A.D.
Hirschhorn, J.N.
Hofman, A.
Hovingh, K.G.
Hsiung, C.A.
Humphries, S.E.
Hunt, S.C.
Hveem, K.
Iribarren, C.
Järvelin, M.R.
Jula, A.
Kähönen, M.
Kaprio, J.
Kesäniemi, A.
Kivimaki, M.
Kooner, J.S.
Koudstaal, P.J.
Krauss, R.M.
Kuh, D
Kuusisto, J.
Kyvik, K.O.
Laakso, M.
Lakka, T.A.
Lind, L.
Lindgren, C.M.
Martin, N.G.
März, W.
McCarthy, M.I.
McKenzie, C.A.
Meneton, P.
Metspalu, A.
Moilanen, L.
Morris, A.D.
Munroe, P.B.
Njolstad, I.
Pedersen, N.L.
Power, C.
Pramstaller, P.P.
Price, J.F.
Psaty, B.M.
Quertermous, T.
Rauramaa, R.
Saleheen, D.
Salomaa, V.
Sanghera, D.K.
Saramies, J.
Schwarz, P.E.
Sheu, W.H.
Shuldiner, A.R.
Siegbahn, A.
Spector, T.D.
Stefansson, K.
Strachan, D.P.
Tayo, B.O.
Tremoli, E.
Tuomilehto, J.
Uusitupa, M.
van Duijn, C.M.
Vollenweider, P.
Wallentin, L.
Wareham, N.J.
Whitfield, J.B.
Wolffenbuttel, B.H.
Ordovas, J.
Boerwinkle, E.
Palmer, C.N.
Thorsteinsdottir, U.
Chasman, D.I.
Rotter, J.I.
Franks, P.W.
Ripatti, S.
Cupples, L.A.
Sandhu, M.S.
Rich, S.S.
Boehnke, M.
Deloukas, P.
Kathiresan, S.
Mohlke, K.L.
Ingelsson, E.
Abecasis, G.R. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Willer , C J , Schmidt , E M , Sengupta , S , Peloso , G M , Gustafsson , S , Kanoni , S , Ganna , A , Chen , J , Buchkovich , M L , Mora , S , Beckmann , J S , Bragg-Gresham , J L , Chang , H Y , Demirkan , A , den Hertog , H M , Do , R , Donnelly , L A , Ehret , G B , Esko , T , Feitosa , M F , Ferreira , T , Fischer , K , Fontanillas , P , Fraser , R M , Freitag , D F , Gurdasani , D , Heikkilä , K , Hyppönen , E , Isaacs , A , Jackson , A U , Johansson , A , Johnson , T , Kaakinen , M , Kettunen , J , Kleber , M E , Li , X , Luan , J , Lyytikäinen , L P , Magnusson , P K , Mangino , M , Mihailov , E , Montasser , M E , Müller-Nurasyid , M , Nolte , I M , O'Connell , J R , Palmer , C D , Perola , M , Petersen , A K , Sanna , S , Saxena , R , Service , S K , Shah , S , Shungin , D , Sidore , C , Song , C , Strawbridge , R J , Surakka , I , Tanaka , T , Teslovich , T M , Thorleifson , G , van den Herik , E G , Voight , B F , Volcik , K A , Waite , L L , Wong , A , Wu , Y , Zhang , W , Absher , D , Asiki , G , Barroso , I , Been , L F , Bolton , J L , Bonnycastle , L L , Brambilla , P , Burnett , M S , Cesana , G , Dimitriou , M , Doney , A S F , Döring , A , Elliott , P , Epstein , S E , Eyjolfsson , G I , Gigante , B , Goodarzi , M O , Grallert , H , Gravito , M L , Groves , C J , Hallmans , G , Hartikainen , A L , Hayward , C , Hernandez , D , Hicks , A A , Holm , H , Hung , Y J , Illig , T , Jones , M R , Kaleebu , P , Kastelein , J J , Khaw , K T , Kim , E , Klopp , N , Komulainen , P , Kumari , M , Langenberg , C , Lehtimäki , T , Lin , S Y , Lindström , J , Loos , R J , Mach , F , McArdle , W L , Meisinger , C , Mitchell , B D , Müller , G , Nagaraja , R , Narisu , N , Nieminen , T V , Nsubuga , R N , Olafsson , I , Ong , K K , Palotie , A , Papamarkou , T , Pomilla , C , Pouta , A , Rader , D J , Reilly , M P , Ridker , P M , Rivadeneira , F , Rudan , I , Ruokonen , A , Samani , N J , Scharnagl , H , Seeley , J , Silander , K , Stancakova , A , Stirrups , K , Swift , A J , Tiret , L , Uitterlinden , A G , van Pelt , L J , Vedantam , S , Wainwright , N W , Wijmenga , C , Wild , S H , Willemsen , G , Wilsgaard , T , Wilson , J F , Young , E H , Zhao , J H , Adair , L S , Arveiler , D , Assimes , T L , Bandinelli , S , Bennett , F , Bochud , M , Boehm , B O , Boomsma , D I , Borecki , I B , Bornstein , S R , Bovet , P , Burnier , M , Campbell , H , Chakravarti , A , Chambers , J C , Chen , Y D , Collins , F S , Cooper , R S , Danesh , J , Dedoussis , G , de Faire , U , Feranil , A B , Ferrières , J , Ferrucci , L , Freimer , N B , Gieger , C , Groop , L C , Gudnason , V , Gyllensten , U , Hamsten , A , Harris , T B , Hingorani , A D , Hirschhorn , J N , Hofman , A , Hovingh , K G , Hsiung , C A , Humphries , S E , Hunt , S C , Hveem , K , Iribarren , C , Järvelin , M R , Jula , A , Kähönen , M , Kaprio , J , Kesäniemi , A , Kivimaki , M , Kooner , J S , Koudstaal , P J , Krauss , R M , Kuh , D , Kuusisto , J , Kyvik , K O , Laakso , M , Lakka , T A , Lind , L , Lindgren , C M , Martin , N G , März , W , McCarthy , M I , McKenzie , C A , Meneton , P , Metspalu , A , Moilanen , L , Morris , A D , Munroe , P B , Njolstad , I , Pedersen , N L , Power , C , Pramstaller , P P , Price , J F , Psaty , B M , Quertermous , T , Rauramaa , R , Saleheen , D , Salomaa , V , Sanghera , D K , Saramies , J , Schwarz , P E , Sheu , W H , Shuldiner , A R , Siegbahn , A , Spector , T D , Stefansson , K , Strachan , D P , Tayo , B O , Tremoli , E , Tuomilehto , J , Uusitupa , M , van Duijn , C M , Vollenweider , P , Wallentin , L , Wareham , N J , Whitfield , J B , Wolffenbuttel , B H , Ordovas , J , Boerwinkle , E , Palmer , C N , Thorsteinsdottir , U , Chasman , D I , Rotter , J I , Franks , P W , Ripatti , S , Cupples , L A , Sandhu , M S , Rich , S S , Boehnke , M , Deloukas , P , Kathiresan , S , Mohlke , K L , Ingelsson , E & Abecasis , G R 2013 , ' Discovery and refinement of loci associated with lipid levels ' , Nature Genetics , vol. 45 , no. 11 , pp. 1274-1283 . https://doi.org/10.1038/ng.2797 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26844062 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/633db0cd-431b-4343-87bc-379cc29b7172 |