AIMS/HYPOTHESIS: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes. METHODS: We measured the levels of 188 metabolites in plasma samples from 130 healthy members of twin families... Mehr ...
| Verfasser: |
Molnos, Sophie
Wahl, Simone
Haid, Mark
Eekhoff, E Marelise W
Pool, René
Floegel, Anna
Deelen, Joris
Much, Daniela
Prehn, Cornelia
Breier, Michaela
Draisma, Harmen H
van Leeuwen, Nienke
Simonis-Bik, Annemarie M C
Jonsson, Anna
Willemsen, Gonneke
Bernigau, Wolfgang
Wang-Sattler, Rui
Suhre, Karsten
Peters, Annette
Thorand, Barbara
Herder, Christian
Rathmann, Wolfgang
Roden, Michael
Gieger, Christian
Kramer, Mark H H
van Heemst, Diana
Pedersen, Helle K
Gudmundsdottir, Valborg
Schulze, Matthias B
Pischon, Tobias
de Geus, Eco J C
Boeing, Heiner
Boomsma, Dorret I
Ziegler, Anette G
Slagboom, P. Eline
Hummel, Sandra
Beekman, Marian
Grallert, Harald
Brunak, Søren
McCarthy, Mark I
Gupta, Ramneek
Pearson, Ewan R
Adamski, Jerzy
't Hart, Leen M |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Molnos , S , Wahl , S , Haid , M , Eekhoff , E M W , Pool , R , Floegel , A , Deelen , J , Much , D , Prehn , C , Breier , M , Draisma , H H , van Leeuwen , N , Simonis-Bik , A M C , Jonsson , A , Willemsen , G , Bernigau , W , Wang-Sattler , R , Suhre , K , Peters , A , Thorand , B , Herder , C , Rathmann , W , Roden , M , Gieger , C , Kramer , M H H , van Heemst , D , Pedersen , H K , Gudmundsdottir , V , Schulze , M B , Pischon , T , de Geus , E J C , Boeing , H , Boomsma , D I , Ziegler , A G , Slagboom , P E , Hummel , S , Beekman , M , Grallert , H , Brunak , S , McCarthy , M I , Gupta , R , Pearson , E R , Adamski , J & 't Hart , L M 2018 , ' Metabolite ratios as potential biomarkers for type 2 diabetes : a DIRECT study ' , Diabetologia , vol. 61 , no. 1 , pp. 117-129 . https://doi.org/10.1007/s00125-017-4436-7 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844018 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/5e7a7e40-a6f8-43d3-8fb0-efa96346690c |
