Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of... Mehr ...
Verfasser: |
Czamara, Darina
Abdellaoui, Abdel
Beekman, Aartjan T.F.
Derks, Eske M.
Dolan, Conor V.
Hottenga, Jouke Jan
Jansen, Rick
Mbarek, Hamdi
Middeldorp, Christel M.
Milaneschi, Yuri
Nivard, Michel G.
Posthuma, Danielle
Boomsma, Dorret I.
Penninx, Brenda W.J.H.
Binder, Elisabeth B. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Czamara , D , Abdellaoui , A , Beekman , A T F , Derks , E M , Dolan , C V , Hottenga , J J , Jansen , R , Mbarek , H , Middeldorp , C M , Milaneschi , Y , Nivard , M G , Posthuma , D , Boomsma , D I , Penninx , B W J H , Binder , E B & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019 , ' Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns ' , Nature Communications , vol. 10 , no. 1 , 2548 , pp. 1-18 . https://doi.org/10.1038/s41467-019-10461-0 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26844007 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/5d921bbc-a6c4-4c9f-8ddc-5717ec0dbe68 |