Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity pr... Mehr ...

Verfasser: Joshi, P.K.
Esko, T.
Mattsson, H.
Eklund, N.
Gandin, I.
Nutile, T.
Jackson, A.U.
Schurmann, C.
Smith, A.V.
Zhang, W.
Okada, Y.
Stancáková, A.
Faul, J.D.
Zhao, W.
Bartz, T.M.
Pina Concas, M.
Franceschini, N.
Enroth, S.
Vitart, V.
Trompet, S.
Guo, X.
Chasman, D.I.
O'Connel, J.R.
Corre, T.
Nongmaithem, S.S.
Chen, Y.
Mangino, M.
Ruggiero, D.
Traglia, M.
Farmaki, A.-E.
Kacprowski, T.
Bjonnes, A.
Spek, A.
Wu, Y.
Giri, A.K.
Yanek, L.R.
Wang, L.
Hofer, E.
Rietveld, C.A.
McLeod, O.
Cornelis, M.C.
Pattaro, C.
Verweij, N.
Baumbach, C.
Abdellaoui, A.
Warren, H.R.
Vuckovic, D.
Mei, H.
Bouchard, C.
Perry, J.R.B.
Cappellani, S.
Mirza, S.S.
Benton, M.C
Broeckel, U.
Medland, S.E.
Lind, P.A.
Malerba, G.
Drong, A.
Yengo, L.
Bielak, L.F.
Zhi, D.
van der Most, P.J.
Shriner, D.
Mägi, R.
Hemani, G.
Karaderi, T.
Wang, Z.
Liu, T.
Demuth, I.
Zhao, J.H.
Meng, W.
Lataniotis, L.
van der Laan, S.W.
Brafdfield, J.P.
Wood, A.R.
Bonnefond, A.
Ahluwalia, T.S.
Hall, L.M.
Salvi, E.
Yazar, S.
Carstensen, L.
de Haan, H.G.
Abney, M.
Afzal, U.
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Amin, N.
Asselbergs, F.W.
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Baumeister, S.E.
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Bergmann, S.
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Yajnik, C.S.
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Zaza, G.
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Salem, R.M.
Melbye, M.
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Samani, N.J.
Cusi, D.
Mackey, D.A.
Cooper, R.S.
Froguel, P.
Pasterkamp, G.
Grant, S.F.A.
Hakonarson, H.
Ferrucci, L.
Scott, R.A.
Morris, A.D.
Palmer, C.N.A.
Dedoussis, G.
Deloukas, P.
Bertram, L.
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Berndt, S.I.
Lindgren, C.M.
Timpson, N.J.
Tönjes, A.
Munroe, P.B.
Sorensen, T.I.A.
Rotimi, C.N.
Arnett, D.K.
Oldehinkel, A.J.
Kardia, S.L.R.
Balkau, B.
Gambaro, G.
Morris, A.P.
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Wright, M.J.
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Hunt, S.C.
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Griffiths, L.R.
Tiemeier, H.
Pirastu, N.
Kaprio, J.
Wareham, N.J.
Pérusse, L.
Wilson, J.G.
Girotto, G.
Caulfield, M.J.
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Boomsma, D.I.
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van der Harst, P.
Hicks, A.A.
Kraft, P.
Sinisalo, J.
Knekt, P.
Johannesson, M.
Magnusson, P.K.E.
Hamsten, A.
Schmidt, R.
Borecki, I.B.
Vartiainen, E.
Becker, D.M.
Bharadwaj, D.
Mohlke, K.L.
Boehnke, M.
van Duijn, C.M.
Sanghera, D.K.
Teumer, A.
Zeggini, E.
Metspalu, A.
Gasparini, P.
Ulivi, S.
Ober, C.
Toniolo, D.
Rudan, I.
Porteous, D.J.
Ciullo, M.
Spector, T.D.
Hayward, C.
Dupuis, J.
Loos, R.J.F.
Wright, A.F.
Chandak, G.R.
Vollenweider, P.
Shuldiner, A.R.
Ridker, P.M.
Rotter, J.I.
Sattar, N.
Gyllensten, U.
North, K.E.
Pirastu, M.
Psaty, B.M.
Weir, D.R.
Laakso, M.
Gudnason, V.
Takahashi, A.
Chambers, J.C.
Kooner, J.S.
Strachan, D.P.
Campbell, H.
Hirschhorn, J.N.
Perola, M.
Polasek, O.
Wilson, J.F.
Dokumenttyp: Artikel
Erscheinungsdatum: 2015
Reihe/Periodikum: Joshi , P K , Esko , T , Mattsson , H , Eklund , N , Gandin , I , Nutile , T , Jackson , A U , Schurmann , C , Smith , A V , Zhang , W , Okada , Y , Stancáková , A , Faul , J D , Zhao , W , Bartz , T M , Pina Concas , M , Franceschini , N , Enroth , S , Vitart , V , Trompet , S , Guo , X , Chasman , D I , O'Connel , J R , Corre , T , Nongmaithem , S S , Chen , Y , Mangino , M , Ruggiero , D , Traglia , M , Farmaki , A-E , Kacprowski , T , Bjonnes , A , Spek , A , Wu , Y , Giri , A K , Yanek , L R , Wang , L , Hofer , E , Rietveld , C A , McLeod , O , Cornelis , M C , Pattaro , C , Verweij , N , Baumbach , C , Abdellaoui , A , Warren , H R , Vuckovic , D , Mei , H , Bouchard , C , Perry , J R B , Cappellani , S , Mirza , S S , Benton , M C , Broeckel , U , Medland , S E , Lind , P A , Malerba , G , Drong , A , Yengo , L , Bielak , L F , Zhi , D , van der Most , P J , Shriner , D , Mägi , R , Hemani , G , Karaderi , T , Wang , Z , Liu , T , Demuth , I , Zhao , J H , Meng , W , Lataniotis , L , van der Laan , S W , Brafdfield , J P , Wood , A R , Bonnefond , A , Ahluwalia , T S , Hall , L M , Salvi , E , Yazar , S , Carstensen , L , de Haan , H G , Abney , M , Afzal , U , Allison , M A , Amin , N , Asselbergs , F W , Bakker , S J L , Barr , R G , Baumeister , S E , Benjamin , D J , Bergmann , S , Boerwinkle , E , Bottinger , E P , Campbell , A , Chakravarti , A , Chan , Y , Chanock , S J , Chen , C , Chen , Y D I , Colins , F S , Connell , J , Correa , A , Cupples , L A , Davey Smith , G , Davies , G , Dörr , M , Ehret , G , Ellis , S B , Feenstra , B , Feitosa , M F , Ford , I , Fox , C S , Frayling , T M , Friedrich , N , Geller , F , Gillham-Nasenya , I , Gottesman , O , Graff , M , Grodstein , F , Gu , C , Haley , C , Hammond , C J , Harris , S E , Harris , T B , Hastie , N D , Heard-Costa , N L , Heikkilä , K , Hocking , L J , Homuth , G , Hottenga , J J , Huang , J , Huffman , J E , Hysi , P G , Arfan Ikram , M , Ingelsson , E , Joensuu , A , Johansson , A , Jousilahti , P , Jukema , J W , Kähönen , M , Kamatani , Y , Kanoni , S , Kerr , S M , Khan , N M , Koellinger , P , Koistinen , H A , Kooner , M K , Kubo , M , Kuusisto , J , Lahti , J , Launer , L J , Lea , R A , Lehne , B , Lehtimäki , T , Liewald , D C M , Lind , L , Loh , M , Lokki , M L , London , S J , Loomis , S J , Loukola , A , Lu , Y , Lumley , T , Lundqvist , A , Männistö , S , Marques-Vidal , P , Masciullo , C , Matchan , A , Mathias , R A , Matsuda , K , Meigs , J B , Meisinger , C , Meitinger , T , Menni , C , Mentch , F D , Mihailov , E , Milani , L , Montasser , M E , Montgomery , G W , Morrison , A , Myers , R H , Nadukuru , R , Navarro , P , Nelis , M , Nieminen , M S , Nolte , I M , O'Connor , G T , Ogunniyi , A , Padmanabhan , S , Palmas , W R , Pankow , J S , Patarcic , I , Pavani , F , Peyser , P A , Pietilainen , K H , Poulter , N , Prokopenko , I , Ralhan , S , Redmond , P , Rich , S S , Rissanen , H , Robino , A , Rose , L M , Rose , R , Sala , C , Salako , B , Salomaa , V , Sarin , A-P , Saxena , R , Schmidt , H , Scott , L J , Scott , W R , Sennblad , B , Seshadri , S , Sever , P , Shrestha , S , Smith , B H , Smith , J A , Soranzo , N , Sotoodehnia , N , Southam , L , Stanton , A V , Stathopoulou , M G , Strauch , K , Strawbridge , R J , Suderman , M J , Tandon , N , Tang , S T , Taylor , K D , Tayo , B O , Töglhofer , A M , Tomaszewski , M , Tsernikova , N , Tuomilehto , J , Uitterlinden , A G , Vaidya , D , Hylckama Vlieg , A , van Setten , J , Vasankari , T , Vedantam , S , Vlachopoulou , E , Vozzi , D , Vuoksimaa , E , Waldenberger , M , Ware , E B , Wentworth-Shields , W , Whitfield , J B , Wild , S , Willemsen , G , Yajnik , C S , Yao , J , Zaza , G , Zhu , X , Salem , R M , Melbye , M , Bisgaard , H , Samani , N J , Cusi , D , Mackey , D A , Cooper , R S , Froguel , P , Pasterkamp , G , Grant , S F A , Hakonarson , H , Ferrucci , L , Scott , R A , Morris , A D , Palmer , C N A , Dedoussis , G , Deloukas , P , Bertram , L , Lindenberger , U , Berndt , S I , Lindgren , C M , Timpson , N J , Tönjes , A , Munroe , P B , Sorensen , T I A , Rotimi , C N , Arnett , D K , Oldehinkel , A J , Kardia , S L R , Balkau , B , Gambaro , G , Morris , A P , Eriksson , J G , Wright , M J , Martin , N G , Hunt , S C , Starr , J M , Deary , I J , Griffiths , L R , Tiemeier , H , Pirastu , N , Kaprio , J , Wareham , N J , Pérusse , L , Wilson , J G , Girotto , G , Caulfield , M J , Raitakari , O , Boomsma , D I , Gieger , C , van der Harst , P , Hicks , A A , Kraft , P , Sinisalo , J , Knekt , P , Johannesson , M , Magnusson , P K E , Hamsten , A , Schmidt , R , Borecki , I B , Vartiainen , E , Becker , D M , Bharadwaj , D , Mohlke , K L , Boehnke , M , van Duijn , C M , Sanghera , D K , Teumer , A , Zeggini , E , Metspalu , A , Gasparini , P , Ulivi , S , Ober , C , Toniolo , D , Rudan , I , Porteous , D J , Ciullo , M , Spector , T D , Hayward , C , Dupuis , J , Loos , R J F , Wright , A F , Chandak , G R , Vollenweider , P , Shuldiner , A R , Ridker , P M , Rotter , J I , Sattar , N , Gyllensten , U , North , K E , Pirastu , M , Psaty , B M , Weir , D R , Laakso , M , Gudnason , V , Takahashi , A , Chambers , J C , Kooner , J S , Strachan , D P , Campbell , H , Hirschhorn , J N , Perola , M , Polasek , O & Wilson , J F 2015 , ' Directional dominance on stature and cognition in diverse human populations ' , Nature , vol. 523 , no. 7561 , pp. 459-462 . https://doi.org/10.1038/nature14618
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26843975
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/5931ba85-caf3-4e2e-bed3-8367f5e87273