Background: Hundreds of genetic variants are thought to contribute to variation in asthma risk by modulating gene expression. Methods that increase the power of genome-wide association studies (GWASs) to identify risk-associated variants are needed. Objective: We sought to develop a method that aggregates the evidence for association with disease risk across expression quantitative trait loci (eQTLs) of a gene and use this approach to identify asthma risk genes. Methods: We developed a gene-based test and software package called EUGENE that (1) is applicable to GWAS summary statistics; (2) con... Mehr ...
Verfasser: |
Ferreira, M.A.R.
Jansen, R.
Willemsen, G.
Penninx, B.W.J.H.
Bain, L.M.
Vicente, C.T.
Revez, J.A.
Matheson, M.C.
Hui, J.
Tung, J.Y.
Baltic, S.
Le Souëf, P.
Montgomery, G.W.
Martin, N.G.
Robertson, C.F.
James, A.
Thompson, P.J.
Boomsma, D.I.
Hopper, J.L.
Hinds, D.A.
Werder, R.B.
Phipps, S. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Ferreira , M A R , Jansen , R , Willemsen , G , Penninx , B W J H , Bain , L M , Vicente , C T , Revez , J A , Matheson , M C , Hui , J , Tung , J Y , Baltic , S , Le Souëf , P , Montgomery , G W , Martin , N G , Robertson , C F , James , A , Thompson , P J , Boomsma , D I , Hopper , J L , Hinds , D A , Werder , R B & Phipps , S 2017 , ' Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling ' , Journal of Allergy and Clinical Immunology , vol. 139 , no. 4 , pp. 1148-1157 . https://doi.org/10.1016/j.jaci.2016.07.017 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26843784 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/43341dc4-dda2-4c11-8e11-18db3f83dea3 |