Metataxonomic Analysis of Individuals at BMI Extremes and Monozygotic Twins Discordant for BMI

Objective: The human gut microbiota has been demonstrated to be associated with a number of host phenotypes, including obesity and a number of obesity-Associated phenotypes. This study is aimed at further understanding and describing the relationship between the gut microbiota and obesity-Associated measurements obtained from human participants. Subjects/Methods: Here, we utilize genetically informative study designs, including a four-corners design (extremes of genetic risk for BMI and of observed BMI; N = 50) and the BMI monozygotic (MZ) discordant twin pair design (N = 30), in order to help... Mehr ...