Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders
BACKGROUND: Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristics. METHODS: Patients (n = 1539) with a DSM-IV MDD diagnosis and control subjects (n = 1792) were from two large cohort studies (Netherlands Study of Depression and Anxiety and Netherlands Twin Register). Genomic profile risk scores (GPRSs) for MDD, bipolar disorder, and SCZ were... Mehr ...
Verfasser: |
Verduijn, Judith
Milaneschi, Yuri
Peyrot, Wouter J
Hottenga, Jouke Jan
Abdellaoui, A.
de Geus, Eco J C
Smit, Johannes H
Breen, Gerome
Lewis, Cathryn M
Boomsma, Dorret I
Beekman, Aartjan T F
Penninx, Brenda W J H |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Verduijn , J , Milaneschi , Y , Peyrot , W J , Hottenga , J J , Abdellaoui , A , de Geus , E J C , Smit , J H , Breen , G , Lewis , C M , Boomsma , D I , Beekman , A T F & Penninx , B W J H 2017 , ' Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders ' , Biological Psychiatry , vol. 81 , no. 4 , pp. 316-324 . https://doi.org/10.1016/j.biopsych.2016.05.024 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26843717 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/3b143454-4dd1-403c-9324-fee1719e11ac |